Next Article in Journal
Kids in a Candy Store: An Objective Analysis of Children’s Interactions with Food in Convenience Stores
Next Article in Special Issue
Urinary Metabolomic Profile of Preterm Infants Receiving Human Milk with Either Bovine or Donkey Milk-Based Fortifiers
Previous Article in Journal
Baseline HOMA IR and Circulating FGF21 Levels Predict NAFLD Improvement in Patients Undergoing a Low Carbohydrate Dietary Intervention for Weight Loss: A Prospective Observational Pilot Study
Article

Effects on Gastroesophageal Reflux of Donkey Milk-Derived Human Milk Fortifier Versus Standard Fortifier in Preterm Newborns: Additional Data from the FortiLat Study

1
Neonatal Care Unit, Sant’Anna Hospital, Città della Salute e della Scienza, Università degli Studi di Torino, 10126 Turin, Italy
2
Institute of Sciences of Food Production, Italian National Research Council, 10126 Turin, Italy
3
Research Centre for Engineering and Agro-Food Processing, Council for Agricultural Research and Economics (CREA), 10100 Turin, Italy
4
Italian Association of Human Milk Banks, Italy
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(7), 2142; https://doi.org/10.3390/nu12072142
Received: 16 June 2020 / Revised: 11 July 2020 / Accepted: 16 July 2020 / Published: 18 July 2020
(This article belongs to the Special Issue Donkey Milk and Infant Nutrition)
Background: Feeding intolerance is a frequent diagnosis in very preterm infants. As seen in the FortiLat trial, human milk fortification with the new donkey milk-derived human milk fortifier (DF) seems to improve feeding tolerance in these infants. The aim of this study was to evaluate the effects of using the DF compared with bovine milk-derived fortifier (BF) on gastroesophageal reflux (GER) in very low birth weight (VLBW) infants. Methods: Over a total of 156 preterm infants were enrolled into the FortiLat trial (GA <32 weeks and birth weight <1500 g) and randomized into the BF arm or DF arm, and we selected all infants with clinical signs of GER and cardiorespiratory (CR) symptoms. All the infants underwent CR and multichannel intraluminal impedance and pH (MII/pH) monitoring associated with gastric ultrasound to evaluate GER and gastric emptying time. Results: 10 infants were enrolled, and 5 were in the DF arm. At MII/pH, infants enrolled into the DF arm showed a lower GER frequency than BF arm infants (p = 0.036). Half gastric emptying time was similar in DF and BF arm infants (p = 0.744). Conclusion: The use of donkey-derived human milk fortifier reduced the GER frequency and consequently should be recommended in infants with feeding intolerance. View Full-Text
Keywords: VLBW; GORD; very preterm; feeding intolerance; tolerance; cardiorespiratory events; MII/pH VLBW; GORD; very preterm; feeding intolerance; tolerance; cardiorespiratory events; MII/pH
Show Figures

Figure 1

MDPI and ACS Style

Cresi, F.; Maggiora, E.; Pirra, A.; Tonetto, P.; Rubino, C.; Cavallarin, L.; Giribaldi, M.; Moro, G.E.; Peila, C.; Coscia, A. Effects on Gastroesophageal Reflux of Donkey Milk-Derived Human Milk Fortifier Versus Standard Fortifier in Preterm Newborns: Additional Data from the FortiLat Study. Nutrients 2020, 12, 2142. https://doi.org/10.3390/nu12072142

AMA Style

Cresi F, Maggiora E, Pirra A, Tonetto P, Rubino C, Cavallarin L, Giribaldi M, Moro GE, Peila C, Coscia A. Effects on Gastroesophageal Reflux of Donkey Milk-Derived Human Milk Fortifier Versus Standard Fortifier in Preterm Newborns: Additional Data from the FortiLat Study. Nutrients. 2020; 12(7):2142. https://doi.org/10.3390/nu12072142

Chicago/Turabian Style

Cresi, Francesco, Elena Maggiora, Alice Pirra, Paola Tonetto, Carlotta Rubino, Laura Cavallarin, Marzia Giribaldi, Guido E. Moro, Chiara Peila, and Alessandra Coscia. 2020. "Effects on Gastroesophageal Reflux of Donkey Milk-Derived Human Milk Fortifier Versus Standard Fortifier in Preterm Newborns: Additional Data from the FortiLat Study" Nutrients 12, no. 7: 2142. https://doi.org/10.3390/nu12072142

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop