Next Article in Journal
Restrained Eating and Vegan, Vegetarian and Omnivore Dietary Intakes
Next Article in Special Issue
The Anti-Inflammatory Effect of Taurine on Cardiovascular Disease
Previous Article in Journal
Dietary Intake and Nitrogen Balance in British Army Infantry Recruits Undergoing Basic Training
Previous Article in Special Issue
The Effect of an Atherogenic Diet and Acute Hyperglycaemia on Endothelial Function in Rabbits Is Artery Specific
Open AccessArticle

The Effect of Dietary Inorganic Nitrate Supplementation on Cardiac Function during Submaximal Exercise in Men with Heart Failure with Reduced Ejection Fraction (HFrEF): A Pilot Study

1
Institute for Health and Sport (IHES), Victoria University, Melbourne, VIC 3011, Australia
2
Australian Institute for Musculoskeletal Science (AIMSS), Western Health, St Albans, VIC 3021, Australia
3
Department of Kinesiology & Division of Cardiovascular Medicine, University of Virginia, Charlottesville, VA 22903, USA
4
Department of Medicine-Western Health, University of Melbourne, St Albans, VIC 3021, Australia
5
Western Health Chronic Disease Alliance, University of Melbourne, St Albans, VIC 3021 Australia
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(7), 2132; https://doi.org/10.3390/nu12072132
Received: 9 April 2020 / Revised: 3 July 2020 / Accepted: 13 July 2020 / Published: 17 July 2020
Heart failure with reduced ejection fraction (HFrEF) is a common end point for patients with coronary artery disease and it is characterized by exercise intolerance due, in part, to a reduction in cardiac output. Nitric oxide (NO) plays a vital role in cardiac function and patients with HFrEF have been identified as having reduced vascular NO. This pilot study aimed to investigate if nitrate supplementation could improve cardiac measures during acute, submaximal exercise. Five male participants (61 ± 3 years) with HFrEF (EF 32 ± 2.2%) completed this pilot study. All participants supplemented with inorganic nitrate (beetroot juice) or a nitrate-depleted placebo for ~13 days prior to testing. Participants completed a three-stage submaximal exercise protocol on a recumbent cycle ergometer with simultaneous echocardiography for calculation of cardiac output (Q), stroke volume (SV), and total peripheral resistance (TPR). Heart rate and blood pressure were measured at rest and during each stage. Both plasma nitrate (mean = ~1028%, p = 0.004) and nitrite (mean = ~109%, p = 0.01) increased following supplementation. There were no differences between interventions at rest, but the percent change in SV and Q from rest to stage two and stage three of exercise was higher following nitrate supplementation (all p > 0.05, ES > 0.8). Both interventions showed decreases in TPR during exercise, but the percent reduction TPR in stages two and three was greater following nitrate supplementation (p = 0.09, ES = 0.98 and p = 0.14, ES = 0.82, respectively). There were clinically relevant increases in cardiac function during exercise following supplementation with nitrate. The findings from this pilot study warrant further investigation in larger clinical trials. View Full-Text
Keywords: nitric oxide; cardiovascular disease; heart failure; cardiac performance nitric oxide; cardiovascular disease; heart failure; cardiac performance
Show Figures

Figure 1

MDPI and ACS Style

Woessner, M.N.; Levinger, I.; Allen, J.D.; McIlvenna, L.C.; Neil, C. The Effect of Dietary Inorganic Nitrate Supplementation on Cardiac Function during Submaximal Exercise in Men with Heart Failure with Reduced Ejection Fraction (HFrEF): A Pilot Study. Nutrients 2020, 12, 2132. https://doi.org/10.3390/nu12072132

AMA Style

Woessner MN, Levinger I, Allen JD, McIlvenna LC, Neil C. The Effect of Dietary Inorganic Nitrate Supplementation on Cardiac Function during Submaximal Exercise in Men with Heart Failure with Reduced Ejection Fraction (HFrEF): A Pilot Study. Nutrients. 2020; 12(7):2132. https://doi.org/10.3390/nu12072132

Chicago/Turabian Style

Woessner, Mary N.; Levinger, Itamar; Allen, Jason D.; McIlvenna, Luke C.; Neil, Christopher. 2020. "The Effect of Dietary Inorganic Nitrate Supplementation on Cardiac Function during Submaximal Exercise in Men with Heart Failure with Reduced Ejection Fraction (HFrEF): A Pilot Study" Nutrients 12, no. 7: 2132. https://doi.org/10.3390/nu12072132

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop