Next Article in Journal
L-Theanine Reduced the Development of Knee Osteoarthritis in Rats via Its Anti-Inflammation and Anti-Matrix Degradation Actions: In Vivo and In Vitro Study
Next Article in Special Issue
Antioxidant Activity with Increased Endogenous Levels of Vitamin C, E and A Following Dietary Supplementation with a Combination of Glutathione and Resveratrol Precursors
Previous Article in Journal
Nutrients and Dietary Patterns Related to Osteoporosis
Previous Article in Special Issue
The Effect of N-Acetylcysteine on Respiratory Enzymes, ADP/ATP Ratio, Glutathione Metabolism, and Nitrosative Stress in the Salivary Gland Mitochondria of Insulin Resistant Rats
Review

Preventive Role of L-Carnitine and Balanced Diet in Alzheimer’s Disease

1
Department of Biochemistry, Radioimmunology and Experimental Medicine, The Children’s Memorial Health Institute, 04-730 Warsaw, Poland
2
Department of Pharmaceutical Biochemistry, Medical University of Bialystok, 15-089 Bialystok, Poland
3
Department of Medical Genetics, Medical University of Bialystok, 15-089 Bialystok, Poland
4
Faculty of Health Sciences, Lomza State University of Applied Sciences, 18-400 Lomza, Poland
5
Department of Psychiatry, Medical University of Bialystok, 15-089 Bialystok, Poland
*
Authors to whom correspondence should be addressed.
Nutrients 2020, 12(7), 1987; https://doi.org/10.3390/nu12071987
Received: 3 June 2020 / Revised: 25 June 2020 / Accepted: 29 June 2020 / Published: 3 July 2020
The prevention or alleviation of neurodegenerative diseases, including Alzheimer’s disease (AD), is a challenge for contemporary health services. The aim of this study was to review the literature on the prevention or alleviation of AD by introducing an appropriate carnitine-rich diet, dietary carnitine supplements and the MIND (Mediterranean-DASH Intervention for Neurodegenerative Delay) diet, which contains elements of the Mediterranean diet and the Dietary Approaches to Stop Hypertension (DASH) diet. L-carnitine (LC) plays a crucial role in the energetic metabolism of the cell. A properly balanced diet contains a substantial amount of LC as well as essential amino acids and microelements taking part in endogenous carnitine synthesis. In healthy people, carnitine biosynthesis is sufficient to prevent the symptoms of carnitine deficiency. In persons with dysfunction of mitochondria, e.g., with AD connected with extensive degeneration of the brain structures, there are often serious disturbances in the functioning of the whole organism. The Mediterranean diet is characterized by a high consumption of fruits and vegetables, cereals, nuts, olive oil, and seeds as the major source of fats, moderate consumption of fish and poultry, low to moderate consumption of dairy products and alcohol, and low intake of red and processed meat. The introduction of foodstuffs rich in carnitine and the MIND diet or carnitine supplementation of the AD patients may improve their functioning in everyday life. View Full-Text
Keywords: Alzheimer’s disease; L-carnitine; carnitine supplementation; Mediterranean diet; MIND diet Alzheimer’s disease; L-carnitine; carnitine supplementation; Mediterranean diet; MIND diet
Show Figures

Figure 1

MDPI and ACS Style

Kepka, A.; Ochocinska, A.; Borzym-Kluczyk, M.; Skorupa, E.; Stasiewicz-Jarocka, B.; Chojnowska, S.; Waszkiewicz, N. Preventive Role of L-Carnitine and Balanced Diet in Alzheimer’s Disease. Nutrients 2020, 12, 1987. https://doi.org/10.3390/nu12071987

AMA Style

Kepka A, Ochocinska A, Borzym-Kluczyk M, Skorupa E, Stasiewicz-Jarocka B, Chojnowska S, Waszkiewicz N. Preventive Role of L-Carnitine and Balanced Diet in Alzheimer’s Disease. Nutrients. 2020; 12(7):1987. https://doi.org/10.3390/nu12071987

Chicago/Turabian Style

Kepka, Alina, Agnieszka Ochocinska, Małgorzata Borzym-Kluczyk, Ewa Skorupa, Beata Stasiewicz-Jarocka, Sylwia Chojnowska, and Napoleon Waszkiewicz. 2020. "Preventive Role of L-Carnitine and Balanced Diet in Alzheimer’s Disease" Nutrients 12, no. 7: 1987. https://doi.org/10.3390/nu12071987

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop