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Open AccessArticle

Influence of Dietary Supplementation for Hyperhomocysteinemia Treatments

1
Institute of Clinical Physiology, National Council of Research (IFC-CNR), ASST Grande Ospedale Metropolitano Niguarda, 20162 Milan, Italy
2
S.S Emostasi, S.C. Ematologia ASST Grande Ospedale Metropolitano Niguarda, 20162 Milan, Italy
3
Driatec srl, Cassina de’ Pecchi, 20060 Milan, Italy
4
Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma Open University, 20122 Milan, Italy
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(7), 1957; https://doi.org/10.3390/nu12071957 (registering DOI)
Received: 26 May 2020 / Revised: 23 June 2020 / Accepted: 29 June 2020 / Published: 30 June 2020
(This article belongs to the Section Nutrition and Metabolism)
Hyperhomocysteinemia is recognized as risk factor for cardiovascular and age-associated diseases. Folic acid supplementation efficiently lowers plasma homocysteine (Hcy) levels, but high intake may negatively affect health because of unnatural levels of unmetabolized folic acid in the systemic circulation. Oxoproline (Oxo) provides by glutamic acid production an increase of intracellular folic acid trapping. Aim of this study was to compare the efficacy of three supplementation protocols: (1) traditional therapy (5-methyl-tetrahydrofolate: 15 mg/day); (2) 5 mL/day of Oxo with 300 μg folic acid (oxifolic); (3) 5 mL/day of Oxo alone (magnesio+) in a 90 days randomized trial on thirty-two moderate hyperhomocysteinemic (18.6 ± 2.4 μmol·L−1) patients (age 48 ± 14 years). Thiols: cysteine (Cys), cysteinylglycine (Cys–Gly) and glutathione levels were assessed too. Every supplementation induced significant (p range <0.05–0.0001) reductions of Hcy level and Cys concentration after the three protocols adopted. Otherwise glutathione concentration significantly increased after oxifolic (p < 0.01) and traditional (p < 0.05) supplementation. The integration of Oxo resulted an interesting alternative to traditional therapy because absence or minimal number of folates in the integrator eliminates any chance of excess that can constitute a long-term risk. View Full-Text
Keywords: magnesium oxoprolinate; folic acid; thiols; homocysteine; randomized study magnesium oxoprolinate; folic acid; thiols; homocysteine; randomized study
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Vezzoli, A.; Dellanoce, C.; Maria Caimi, T.; Vietti, D.; Montorsi, M.; Mrakic-Sposta, S.; Accinni, R. Influence of Dietary Supplementation for Hyperhomocysteinemia Treatments. Nutrients 2020, 12, 1957.

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