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Open AccessArticle

Consumption of Stilbenes and Flavonoids is Linked to Reduced Risk of Obesity Independently of Fiber Intake

1
Department of Twin Research & Genetic Epidemiology, King’s College London, St Thomas’ Hospital Campus, Westminster Bridge Road, London SE1 7EH, UK
2
Department of Nutritional Sciences, King’s College London, Franklin-Wilkins Building, Stamford St, London SE1 9NH, UK
3
NIHR Biomedical Research Centre at Guy’s and St Thomas’ Foundation Trust, London SE1 9RT, UK
4
Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, UK
5
Academic Rheumatology, University of Nottingham, Hucknall Road, Nottingham NG5 1PB, UK
*
Authors to whom correspondence should be addressed.
Equal contribution.
Nutrients 2020, 12(6), 1871; https://doi.org/10.3390/nu12061871
Received: 14 May 2020 / Revised: 15 June 2020 / Accepted: 18 June 2020 / Published: 23 June 2020
(This article belongs to the Special Issue Dietary (Poly)Phenols and Health)
Background: Polyphenol consumption is implicated in gut microbiome composition and improved metabolic outcomes, but it is unclear whether the effect is independent of dietary fiber. Methods: We investigated the links between (poly)phenol intake, gut microbiome composition (16s RNA) and obesity independently of fiber intake in UK women (n = 1810) and in a small group of UK men (n = 64). Results: (Poly)phenol intakes correlated with microbiome alpha diversity (Shannon Index) after adjusting for confounders and fiber intake. Moreover, flavonoid intake was significantly correlated with the abundance of Veillonella, (a genus known to improve physical performance), and stilbene intake with that of butyrate-producing bacteria (Lachnospira and Faecalibacterium). Stilbene and flavonoid intake also correlated with lower odds of prevalent obesity (Stilbenes: Odds Ratio (95% Confidence Interval) (OR(95%CI)) = 0.80 (0.73, 0.87), p = 4.90 × 10−7; Flavonoids: OR(95%CI) = 0.77 (0.65, 0.91), p = 0.002). Formal mediation analyses revealed that gut microbiome mediates ~11% of the total effect of flavonoid and stilbene intake on prevalent obesity. Conclusions: Our findings highlight the importance of (poly)phenol consumption for optimal human health. View Full-Text
Keywords: polyphenol intake; obesity; gut microbiome diversity; gut microbiome composition; fiber intake; stilbene intake; flavonoid intake polyphenol intake; obesity; gut microbiome diversity; gut microbiome composition; fiber intake; stilbene intake; flavonoid intake
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Mompeo, O.; Spector, T.D.; Matey Hernandez, M.; Le Roy, C.; Istas, G.; Le Sayec, M.; Mangino, M.; Jennings, A.; Rodriguez-Mateos, A.; Valdes, A.M.; Menni, C. Consumption of Stilbenes and Flavonoids is Linked to Reduced Risk of Obesity Independently of Fiber Intake. Nutrients 2020, 12, 1871.

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