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Nutrients
Volume 12
Issue 6
10.3390/nu12061732
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Article

Poor Adherence to Mediterranean Diet and Serum Lipopolysaccharide Are Associated with Oxidative Stress in Patients with Non-Alcoholic Fatty Liver Disease

by
Francesco Baratta
1,†,
Daniele Pastori
1,†,
Simona Bartimoccia
1,
Vittoria Cammisotto
1,
Nicholas Cocomello
1,
Alessandra Colantoni
1,
Cristina Nocella
1,
Roberto Carnevale
2,3,
Domenico Ferro
1,
Francesco Angelico
4,*,‡,
Francesco Violi
1,3,‡ and
Maria Del Ben
1,‡
1
I Clinica Medica, Department of Clinical Internal, Anestesiological and Cardiovascular Sciences, Sapienza University of Rome, 00185 Roma, Italy
2
Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04015 Latina, Italy
3
Mediterranea Cardio Centro, 80122 Napoli, Italy
4
Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Roma, Italy
*
Author to whom correspondence should be addressed.
†
These authors are joint first authors and contributed equally to this work.
‡
These authors are joint last authors and contributed equally to this work.
Nutrients 2020, 12(6), 1732; https://doi.org/10.3390/nu12061732
Received: 22 April 2020 / Revised: 5 June 2020 / Accepted: 7 June 2020 / Published: 10 June 2020
(This article belongs to the Special Issue The Role of Diet in Fatty Liver Disease)
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Abstract

Oxidative stress plays a pivotal role in non-alcoholic fatty liver disease (NAFLD). Factors inducing oxidative stress in NAFLD may be several; however, a relationship with the adherence to Mediterranean Diet (Med-diet) and with serum lipopolysaccharide (LPS) has been poorly investigated in this setting. The aim was to investigate factors associated with impaired oxidative stress in NAFLD, focusing on the potential role of LPS and Med-diet. We enrolled 238 consecutive outpatients from the PLINIO study, in whom we measured the soluble Nox2-derived peptide (sNox2-dp), a marker of systemic oxidative stress, and serum LPS. Adherence to Med-diet was investigated by a nine-item validated dietary questionnaire. Serum sNox2-dp and LPS were higher in patients with NAFLD compared to those without (25.0 vs. 9.0 pg/mL, p < 0.001 and 62.0 vs. 44.9 pg/mL, p < 0.001, respectively). In patients with NAFLD, the highest sNox2-dp tertile was associated with the top serum LPS tertile (Odds Ratio (OR): 4.71; p < 0.001), APRI > 0.7 (OR: 6.96; p = 0.005) and Med-diet-score > 6 (OR: 0.14; p = 0.026). Analyzing individual foods, the daily consumption of wine (OR: 0.29, p = 0.046) and the adequate weekly consumption of fish (OR: 0.32, p = 0.030) inversely correlated with the top sNox2-dp tertile. In conclusion, patients with NAFLD showed impaired oxidative stress. Levels of sNox2 correlated with serum LPS and with low adherence to Med-Diet. View Full-Text
Keywords: Non-alcoholic fatty liver disease; Mediterranean diet; oxidative stress; lipopolysaccharide; Nox2-derived peptide Non-alcoholic fatty liver disease; Mediterranean diet; oxidative stress; lipopolysaccharide; Nox2-derived peptide
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MDPI and ACS Style

Baratta, F.; Pastori, D.; Bartimoccia, S.; Cammisotto, V.; Cocomello, N.; Colantoni, A.; Nocella, C.; Carnevale, R.; Ferro, D.; Angelico, F.; Violi, F.; Del Ben, M. Poor Adherence to Mediterranean Diet and Serum Lipopolysaccharide Are Associated with Oxidative Stress in Patients with Non-Alcoholic Fatty Liver Disease. Nutrients 2020, 12, 1732. https://doi.org/10.3390/nu12061732

AMA Style

Baratta F, Pastori D, Bartimoccia S, Cammisotto V, Cocomello N, Colantoni A, Nocella C, Carnevale R, Ferro D, Angelico F, Violi F, Del Ben M. Poor Adherence to Mediterranean Diet and Serum Lipopolysaccharide Are Associated with Oxidative Stress in Patients with Non-Alcoholic Fatty Liver Disease. Nutrients. 2020; 12(6):1732. https://doi.org/10.3390/nu12061732

Chicago/Turabian Style

Baratta, Francesco, Daniele Pastori, Simona Bartimoccia, Vittoria Cammisotto, Nicholas Cocomello, Alessandra Colantoni, Cristina Nocella, Roberto Carnevale, Domenico Ferro, Francesco Angelico, Francesco Violi, and Maria Del Ben. 2020. "Poor Adherence to Mediterranean Diet and Serum Lipopolysaccharide Are Associated with Oxidative Stress in Patients with Non-Alcoholic Fatty Liver Disease" Nutrients 12, no. 6: 1732. https://doi.org/10.3390/nu12061732

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