Next Article in Journal
Plate Waste Generated by Spanish Households and Out-of-Home Consumption: Results from the ANIBES Study
Previous Article in Journal
Pathophysiological Mechanisms by which Heat Stress Potentially Induces Kidney Inflammation and Chronic Kidney Disease in Sugarcane Workers
Article

Ubiquinol-10 Intake Is Effective in Relieving Mild Fatigue in Healthy Individuals

by 1,2,3,4, 1,2,3,4, 1,2,3 and 1,2,3,*
1
Osaka City University Center for Health Science Innovation, Osaka 530-0011, Japan
2
RIKEN Compass to Healthy Life Research Complex Program, Kobe, Hyogo 650-0047, Japan
3
Laboratory for Pathophysiological and Health Science, RIKEN Center for Biosystems Dynamics Research, Kobe, Hyogo 650-0047, Japan
4
Department of Medical Science on Fatigue, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(6), 1640; https://doi.org/10.3390/nu12061640
Received: 17 April 2020 / Revised: 20 May 2020 / Accepted: 28 May 2020 / Published: 2 June 2020
(This article belongs to the Section Clinical Nutrition)
Our double-blind, placebo-controlled study evaluated effects of ubiquinol, the reduced form of coenzyme Q10, on mild fatigue in healthy individuals experiencing fatigue in daily life that had continued for more than 1 and less than 6 months. The participants received 100-mg/day (Ubq100; age 44.0 ± 9.8 years; 14 females and 6 males) or 150-mg/day ubiquinol (Ubq150; age 40.4 ± 11.8 years; 14 females and 8 males) or placebo (Plc; age 41.3 ± 13.4 years; 13 females and 7 males) daily for 12 weeks. Measurements of subjective and objective fatigue were conducted by using questionnaires-based fatigue scales/visual analogue scales and autonomic nerve function/biological oxidation index, respectively, prior to the first dosing and every 4 weeks thereafter. Serum ubiquinol level increased three- to four-fold after 4 weeks and remained significantly higher than that after Plc administration throughout the intake period. Although a higher blood level of ubiquinol was observed with Ubq150 than with Ubq100, the difference was not statistically significant. In both Ubq100 and Ubq150 groups, subjective levels of fatigue sensation and sleepiness after cognitive tasks, which consisted of the modified Advanced Trail Making Test, the modified Stroop Color-Word Test, and the Digit Symbol Substitution Test, improved significantly compared with those in the placebo group, suggesting an anti-fatigue effect. The Ubq150 group demonstrated significant improvement compared with the Plc group regarding subjective level of relaxation after task, sleepiness before and after task, motivation for task, and serum level of oxidative stress. Correlation analysis between blood level of ubiquinol and each evaluated effect suggested a positive relationship with relaxation after task, motivation for cognitive task, and parasympathetic activity. The results of the study suggest that ubiquinol intake relieves mild fatigue in healthy individuals. View Full-Text
Keywords: ubiquinol; fatigue; oxidative stress; autonomic nerve function; motivation; cognitive function ubiquinol; fatigue; oxidative stress; autonomic nerve function; motivation; cognitive function
Show Figures

Figure 1

MDPI and ACS Style

Mizuno, K.; Sasaki, A.T.; Watanabe, K.; Watanabe, Y. Ubiquinol-10 Intake Is Effective in Relieving Mild Fatigue in Healthy Individuals. Nutrients 2020, 12, 1640. https://doi.org/10.3390/nu12061640

AMA Style

Mizuno K, Sasaki AT, Watanabe K, Watanabe Y. Ubiquinol-10 Intake Is Effective in Relieving Mild Fatigue in Healthy Individuals. Nutrients. 2020; 12(6):1640. https://doi.org/10.3390/nu12061640

Chicago/Turabian Style

Mizuno, Kei, Akihiro T. Sasaki, Kyosuke Watanabe, and Yasuyoshi Watanabe. 2020. "Ubiquinol-10 Intake Is Effective in Relieving Mild Fatigue in Healthy Individuals" Nutrients 12, no. 6: 1640. https://doi.org/10.3390/nu12061640

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop