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Effect of Deglycosylated Rutin by Acid Hydrolysis on Obesity and Hyperlipidemia in High-Fat Diet-Induced Obese Mice

1
Division of Food and Animal Sciences, Chungbuk National University, Cheongju, Chungbuk 28644, Korea
2
School of Food Biotechnology and Nutrition, Kyungsung University, Busan 48434, Korea
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(5), 1539; https://doi.org/10.3390/nu12051539
Received: 21 April 2020 / Revised: 19 May 2020 / Accepted: 22 May 2020 / Published: 25 May 2020
(This article belongs to the Section Phytochemicals and Human Health)
The present study evaluated the effects of acid-treated rutin on hyperlipidemia and obesity in high-fat diet (HFD)-induced obese mice. The mice consumed a HFD with or without acid-treated rutin for 7 weeks. Body weight gain considerably decreased, by approximately 33%, in the acid-treated rutin (AR) and quercetin (Q) groups compared to that in the HFD group. The adipocytes’ size in epididymal fat in AR and Q groups was significantly reduced compared to that in the HFD group (p < 0.05). Treatment with AR decreased the levels of triglycerides, total cholesterol, and low-density lipoprotein cholesterol compared to the HFD group. In particular, administration of AR significantly decreased serum triglyceride (36.82 mg/dL) by 46% compared to HFD (69.30 mg/dL). The AR group also showed significantly decreased atherogenic indices and cardiac risk factors. These results suggest that deglycosylated rutin generated by acid treatment enhances the anti-obesity and hypolipidemic effects in obese mice, and provides valuable information for improving the functional properties of glycosidic flavonoids. View Full-Text
Keywords: rutin; aglycone; quercetin; deglycosylation; obesity rutin; aglycone; quercetin; deglycosylation; obesity
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MDPI and ACS Style

Yang, J.; Lee, J.; Kim, Y. Effect of Deglycosylated Rutin by Acid Hydrolysis on Obesity and Hyperlipidemia in High-Fat Diet-Induced Obese Mice. Nutrients 2020, 12, 1539. https://doi.org/10.3390/nu12051539

AMA Style

Yang J, Lee J, Kim Y. Effect of Deglycosylated Rutin by Acid Hydrolysis on Obesity and Hyperlipidemia in High-Fat Diet-Induced Obese Mice. Nutrients. 2020; 12(5):1539. https://doi.org/10.3390/nu12051539

Chicago/Turabian Style

Yang, Jinwoo, Junsoo Lee, and Younghwa Kim. 2020. "Effect of Deglycosylated Rutin by Acid Hydrolysis on Obesity and Hyperlipidemia in High-Fat Diet-Induced Obese Mice" Nutrients 12, no. 5: 1539. https://doi.org/10.3390/nu12051539

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