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Open AccessArticle

Clinical and Nutritional Effectiveness of a Nutritional Protocol with Oligomeric Enteral Nutrition in Patients with Oncology Treatment-Related Diarrhea

1
Department of Endocrinology and Nutrition, Miguel Servet Hospital, 50009 Zaragoza, Spain
2
Instituto de Investigación Sanitaria Aragón (IIS Aragon), 50009 Zaragoza, Spain
3
Department of Oncology, Miguel Servet Hospital, 50009 Zaragoza, Spain
4
Department of Oncology, University Clinic Hospital, 50009 Zaragoza, Spain
5
Department of Endocrinology and Nutrition, University Clinic Hospital, 50009 Zaragoza, Spain
6
Group Research on Wellbeing (GRoW), Blanquerna School of Health Sciences–Universitat Ramon Llull, 08025 Barcelona, Spain
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(5), 1534; https://doi.org/10.3390/nu12051534
Received: 16 April 2020 / Revised: 19 May 2020 / Accepted: 23 May 2020 / Published: 25 May 2020
(This article belongs to the Section Clinical Nutrition)
(1) Background: Poor nutritional status and diarrhea are common complications in cancer patients. (2) Methods: This multicenter, observational, prospective study evaluated the effectiveness of an oligomeric enteral nutrition (OEN) protocol in the improvement of nutritional status and reduction of diarrhea symptoms. Nutritional status was assessed with the Subjective Global Assessment (SGA), Body Mass Index (BMI) and albumin levels. Diarrhea was evaluated by the frequency and consistency of stools (Bristol Stool form scale). (3) Results: After 8 weeks of OEN protocol, the nutritional status improved in 48.3% of patients, with an increased proportion of patients at risk of malnourishment (+27.3%) at the expense of a decrease of moderately (−19.9%) and severely (−7.3%) malnourished patients (p < 0.001). Serum albumin and BMI significantly increased after 8 weeks of OEN treatment (p < 0.005). OEN showed a 71.1% effectiveness in the improvement of stool consistency. The mean number of stools per day significantly decreased from baseline (4.17 stools/day) to week 8 (1.42 stools/day; p = 0.0041). The nutritional status significantly improved even in those patients with persistent diarrhea. (4) Conclusion: The proposed OEN protocol seemed to be effective in improving the nutritional status, frequency and consistency of stools in patients with oncology treatment-related diarrhea even in persistent cases. View Full-Text
Keywords: oncology treatment-related diarrhea; nutritional protocol; oligomeric enteral nutrition oncology treatment-related diarrhea; nutritional protocol; oligomeric enteral nutrition
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Sanz-Paris, A.; Martinez-Trufero, J.; Lambea-Sorrosal, J.; Calvo-Gracia, F.; Milà-Villarroel, R. Clinical and Nutritional Effectiveness of a Nutritional Protocol with Oligomeric Enteral Nutrition in Patients with Oncology Treatment-Related Diarrhea. Nutrients 2020, 12, 1534.

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