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Article

Tart Cherry Increases Lifespan in Caenorhabditis elegans by Altering Metabolic Signaling Pathways

1
Department of Nutritional Sciences, Obesity Research Institute, Texas Tech University, Lubbock, TX 79409, USA
2
Department of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA
3
Department of Chemical Engineering, Texas Tech University, Lubbock, TX 79409, USA
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(5), 1482; https://doi.org/10.3390/nu12051482
Received: 24 March 2020 / Revised: 1 May 2020 / Accepted: 15 May 2020 / Published: 20 May 2020
(This article belongs to the Section Nutrigenetics and Nutrigenomics)
Aging and healthspan are determined by both environmental and genetic factors. The insulin/insulin-like growth factor-1(IGF-1) pathway is a key mediator of aging in Caenorhabditis elegans and mammals. Specifically, DAF-2 signaling, an ortholog of human IGF, controls DAF-16/FOXO transcription factor, a master regulator of metabolism and longevity. Moreover, mitochondrial dysfunction and oxidative stress are both linked to aging. We propose that daily supplementation of tart cherry extract (TCE), rich in anthocyanins with antioxidant properties may exert dual benefits for mitochondrial function and oxidative stress, resulting in beneficial effects on aging in C. elegans. We found that TCE supplementation at 6 μg or 12 μg/mL, increased (p < 0.05) the mean lifespan of wild type N2 worms, respectively, when compared to untreated control worms. Consistent with these findings, TCE upregulated (p < 0.05) expression of longevity-related genes such as daf-16 and aak-2 (but not daf-2 or akt-1 genes) and genes related to oxidative stress such as sod-2. Further, we showed that TCE supplementation increased spare respiration in N2 worms. However, TCE did not change the mean lifespan of daf-16 and aak-2 mutant worms. In conclusion, our findings indicate that TCE confers healthspan benefits in C. elegans through enhanced mitochondrial function and reduced oxidative stress, mainly via the DAF-16 pathway. View Full-Text
Keywords: C. elegans; tart cherry; lifespan; aging; oxidative stress; daf-16 C. elegans; tart cherry; lifespan; aging; oxidative stress; daf-16
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MDPI and ACS Style

Jayarathne, S.; Ramalingam, L.; Edwards, H.; Vanapalli, S.A.; Moustaid-Moussa, N. Tart Cherry Increases Lifespan in Caenorhabditis elegans by Altering Metabolic Signaling Pathways. Nutrients 2020, 12, 1482. https://doi.org/10.3390/nu12051482

AMA Style

Jayarathne S, Ramalingam L, Edwards H, Vanapalli SA, Moustaid-Moussa N. Tart Cherry Increases Lifespan in Caenorhabditis elegans by Altering Metabolic Signaling Pathways. Nutrients. 2020; 12(5):1482. https://doi.org/10.3390/nu12051482

Chicago/Turabian Style

Jayarathne, Shasika, Latha Ramalingam, Hunter Edwards, Siva A. Vanapalli, and Naima Moustaid-Moussa. 2020. "Tart Cherry Increases Lifespan in Caenorhabditis elegans by Altering Metabolic Signaling Pathways" Nutrients 12, no. 5: 1482. https://doi.org/10.3390/nu12051482

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