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The Effect of Ursodeoxycholic Acid on Small Intestinal Bacterial Overgrowth in Patients with Functional Dyspepsia: A Pilot Randomized Controlled Trial

Department of Family Practice and Community Health, Ajou University School of Medicine, Suwon 16499, Korea
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Nutrients 2020, 12(5), 1410; https://doi.org/10.3390/nu12051410
Received: 3 April 2020 / Revised: 29 April 2020 / Accepted: 13 May 2020 / Published: 14 May 2020
(This article belongs to the Section Clinical Nutrition)
Functional dyspepsia (FD) is associated with small intestinal bacterial overgrowth (SIBO). Several animal studies have reported that ursodeoxycholic acid (UDCA) has antibacterial and anti-inflammatory effects in the intestine. We hypothesized that UDCA may be effective against dyspeptic symptoms and SIBO in patients with FD. We conducted this randomized controlled trial to investigate the effects of UDCA in FD patients with SIBO. Twenty-four patients diagnosed with FD and SIBO based on lactulose breath test (LBT) were randomly assigned to either a UDCA treatment group or an untreated group. The treatment group received 100 mg of UDCA three times per day for two months; the untreated group was monitored for two months without intervention. After two months in both groups, we reevaluated LBT and FD symptoms using the Nepean dyspepsia index-K. FD symptoms in the UDCA-treated group were significantly reduced after two months compared with baseline and FD symptom scores between the UDCA-treated and untreated groups showed statistically significant differences after two months. In addition, the total methane gas levels for 90 minutes in LBT were significantly decreased after two months compared with baseline in the UDCA-treated group. In this preliminary exploratory study, we found that two months of UDCA treatment resulted in FD symptom improvement and reduced methane values during 90 minutes on the LBT, suggesting that methane-producing SIBO were associated with symptoms of dyspepsia and that UDCA was helpful in these patients. These findings need to be validated via large-scale controlled and well-designed studies. View Full-Text
Keywords: functional dyspepsia; small intestinal bacterial overgrowth; ursodeoxycholic acid functional dyspepsia; small intestinal bacterial overgrowth; ursodeoxycholic acid
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MDPI and ACS Style

Kim, B.-T.; Kim, K.-M.; Kim, K.-N. The Effect of Ursodeoxycholic Acid on Small Intestinal Bacterial Overgrowth in Patients with Functional Dyspepsia: A Pilot Randomized Controlled Trial. Nutrients 2020, 12, 1410. https://doi.org/10.3390/nu12051410

AMA Style

Kim B-T, Kim K-M, Kim K-N. The Effect of Ursodeoxycholic Acid on Small Intestinal Bacterial Overgrowth in Patients with Functional Dyspepsia: A Pilot Randomized Controlled Trial. Nutrients. 2020; 12(5):1410. https://doi.org/10.3390/nu12051410

Chicago/Turabian Style

Kim, Bom-Taeck, Kwang-Min Kim, and Kyu-Nam Kim. 2020. "The Effect of Ursodeoxycholic Acid on Small Intestinal Bacterial Overgrowth in Patients with Functional Dyspepsia: A Pilot Randomized Controlled Trial" Nutrients 12, no. 5: 1410. https://doi.org/10.3390/nu12051410

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