Next Article in Journal
Role of Nutrition in Prevention of Neonatal Spontaneous Intestinal Perforation and Its Complications: A Systematic Review
Previous Article in Journal
Antitumor, Anti-inflammatory and Antiallergic Effects of Agaricus blazei Mushroom Extract and the Related Medicinal Basidiomycetes Mushrooms, Hericium erinaceus and Grifola frondosa: A Review of Preclinical and Clinical Studies
Editorial

High Intake of Sugar and the Balance between Pro- and Anti-Inflammatory Gut Bacteria

Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, FI-00014 Helsinki, Finland
Nutrients 2020, 12(5), 1348; https://doi.org/10.3390/nu12051348
Received: 23 April 2020 / Accepted: 24 April 2020 / Published: 8 May 2020
The so-called Western diet is rich in saturated fat and sugars and poor in plant-derived fibers, and it is associated with an increased risk of metabolic and cardiovascular diseases, as well as chronic (low grade) inflammation. The detrimental effects of poor diet are in part mediated by gut microbiota, whose composition, functionality and metabolic end products respond to dietary changes. Recent studies have shown that high intake of sugars increase the relative abundance of Proteobacteria in the gut, while simultaneously decreasing the abundance of Bacteroidetes, which can mitigate the effects of endotoxin, as well as reinforce gut barrier function. Thus, a high sugar intake may stagger the balance of microbiota to have increased pro-inflammatory properties and decreased the capacity to regulate epithelial integrity and mucosal immunity. Consequently, high dietary sugar can, through the modulation of microbiota, promote metabolic endotoxemia, systemic (low grade) inflammation and the development of metabolic dysregulation and thereby, high dietary sugar may have many-fold deleterious health effects, in addition to providing excess energy. View Full-Text
Keywords: glucose; fructose; gut microbiota; inflammation; immunoregulation; Proteobacteria; Enterobacteriaceae; LPS; Bacteroidetes; Bacteroides glucose; fructose; gut microbiota; inflammation; immunoregulation; Proteobacteria; Enterobacteriaceae; LPS; Bacteroidetes; Bacteroides
MDPI and ACS Style

Satokari, R. High Intake of Sugar and the Balance between Pro- and Anti-Inflammatory Gut Bacteria. Nutrients 2020, 12, 1348. https://doi.org/10.3390/nu12051348

AMA Style

Satokari R. High Intake of Sugar and the Balance between Pro- and Anti-Inflammatory Gut Bacteria. Nutrients. 2020; 12(5):1348. https://doi.org/10.3390/nu12051348

Chicago/Turabian Style

Satokari, Reetta. 2020. "High Intake of Sugar and the Balance between Pro- and Anti-Inflammatory Gut Bacteria" Nutrients 12, no. 5: 1348. https://doi.org/10.3390/nu12051348

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop