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Article

The Disruption of Liver Metabolic Circadian Rhythms by a Cafeteria Diet Is Sex-Dependent in Fischer 344 Rats

1
Nutrigenomics Research Group, Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, 43007 Tarragona, Spain
2
Eurecat, Centre Tecnològic de Catalunya, Centre for Omic Sciences (COS), Joint Unit Univeristat Rovira i Virgili-EURECAT, Unique Scientific and Technical Infrastructures (ICTS), 43204 Reus, Spain
*
Author to whom correspondence should be addressed.
Both authors contributed equally to this manuscript.
Nutrients 2020, 12(4), 1085; https://doi.org/10.3390/nu12041085
Received: 26 February 2020 / Revised: 10 April 2020 / Accepted: 11 April 2020 / Published: 14 April 2020
(This article belongs to the Section Nutrition and Metabolism)
Circadian rhythms are ~24 h fluctuations of different biological processes that are regulated by the circadian clock system. They exert a major influence on most of the metabolism, such as the hepatic metabolism. This rhythmicity can be disrupted by obesogenic diets, fact that is considered to be a risk factor for the development of metabolic diseases. Nevertheless, obesogenic diets do not affect both genders in the same manner. We hypothesized that the circadian rhythms disruption of the hepatic metabolism, caused by obesogenic diets, is gender-dependent. Male and female Fischer 344 rats were fed either a standard diet or a cafeteria diet and sacrificed at two different moments, at zeitgeber 3 and 15. Only female rats maintained the circadian variations of the hepatic metabolism under a cafeteria diet. Most of those metabolites were related with the very low density lipoprotein (VLDL) synthesis, such as choline, betaine or phosphatidylcholine. Most of these metabolites were found to be increased at the beginning of the dark period. On the other hand, male animals did not show these time differences. These findings suggest that females might be more protected against the circadian disruption of the hepatic metabolism caused by a cafeteria diet through the increase of the VLDL synthesis at the beginning of the feeding time. View Full-Text
Keywords: circadian rhythms; obesity; gender; liver; metabolomics circadian rhythms; obesity; gender; liver; metabolomics
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MDPI and ACS Style

Palacios-Jordan, H.; Martín-González, M.Z.; Suárez, M.; Aragonès, G.; Muguerza, B.; Rodríguez, M.A.; Bladé, C. The Disruption of Liver Metabolic Circadian Rhythms by a Cafeteria Diet Is Sex-Dependent in Fischer 344 Rats. Nutrients 2020, 12, 1085. https://doi.org/10.3390/nu12041085

AMA Style

Palacios-Jordan H, Martín-González MZ, Suárez M, Aragonès G, Muguerza B, Rodríguez MA, Bladé C. The Disruption of Liver Metabolic Circadian Rhythms by a Cafeteria Diet Is Sex-Dependent in Fischer 344 Rats. Nutrients. 2020; 12(4):1085. https://doi.org/10.3390/nu12041085

Chicago/Turabian Style

Palacios-Jordan, Héctor; Martín-González, Miguel Z.; Suárez, Manuel; Aragonès, Gerard; Muguerza, Begoña; Rodríguez, Miguel A.; Bladé, Cinta. 2020. "The Disruption of Liver Metabolic Circadian Rhythms by a Cafeteria Diet Is Sex-Dependent in Fischer 344 Rats" Nutrients 12, no. 4: 1085. https://doi.org/10.3390/nu12041085

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