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Neonatal Vitamin D Status and Risk of Asthma in Childhood: Results from the D-Tect Study

Research Unit for Dietary Studies, The Parker Institute, Bisbebjerg og Frederiksberg Hospital, Nordre Fasanvej 57, 2000 Frederiksberg, Denmark
Danish Center for Neonatal Screening, Department of Clinical Biochemistry and Immunology, Statens Serum Institute, 2300 Copenhagen, Denmark
Department of Primary Care and Public Health, Imperial College London, London W6 8RP, UK
Centre for Fetal Programming, Department of Epidemiology Research, Statens Serum Institut, 2300 Copenhagen, Denmark
Department of Pharmacy, University of Copenhagen, 2100 Denmark
Center for Physical Activity Research, Rigshospitalet and Copenhagen University, 2100 Copenhagen, Denmark
The Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders, University of Sidney, Sidney, NSW 2006, Australia
The Department of Public Health, Section for General Medicine, University of Copenhagen, 2100 Copenhagen, Denmark
Author to whom correspondence should be addressed.
Nutrients 2020, 12(3), 842;
Received: 3 February 2020 / Revised: 17 March 2020 / Accepted: 18 March 2020 / Published: 21 March 2020
(This article belongs to the Special Issue Parental Diet for Offspring Health)
Background: low vitamin D status in pregnancy can influence the offspring’s lung function and contribute to childhood asthma development. The objective of this study was to examine the influence of neonatal vitamin D status on the development of asthma among children age 3–9 years in a large population sample. Method: in a case-cohort study utilizing a Danish biobank and register data we examined the association between neonatal 25-hydroxyvitamin D3 (25(OH)D3) concentrations and incidence of asthma among children aged 3–9 years. Cases of asthma (n = 911) were randomly selected among all cases of asthma in the Danish National Patient Register from children born between 1992 and 2002. The sub-cohort (n = 1423) was randomly selected among all children born in the same period. We used a weighted Cox proportional hazard model assessing the hazard of first asthma diagnoses by quintiles of 25(OH)D3. Results: the median 25(OH)D3 (interquartile range) for asthma cases was 23 nmol/L (14–35) and the sub-cohort 25 nmol/L (14–40). The hazard ratio for developing asthma between ages 3 and 9 years was lower for children in the fifth quintile of neonatal 25(OH)D3 compared to children in the first quintile, both in the unadjusted (0.61 95% CI: 0.46–0.80) and adjusted (0.55 95% CI: 0.39–0.77) analyses. Conclusion: the results from our study suggest that higher neonatal vitamin D concentration may reduce the risk of developing childhood asthma at ages 3–9 years, indicating that neonatal vitamin D status as a proxy of vitamin D status during the prenatal period is important for normal immune- and lung development. View Full-Text
Keywords: neonatal; vitamin D; asthma; childhood neonatal; vitamin D; asthma; childhood
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MDPI and ACS Style

Thorsteinsdottir, F.; Cardoso, I.; Keller, A.; Stougaard, M.; Frederiksen, P.; Cohen, A.S.; Maslova, E.; Jacobsen, R.; Backer, V.; Heitmann, B.L. Neonatal Vitamin D Status and Risk of Asthma in Childhood: Results from the D-Tect Study. Nutrients 2020, 12, 842.

AMA Style

Thorsteinsdottir F, Cardoso I, Keller A, Stougaard M, Frederiksen P, Cohen AS, Maslova E, Jacobsen R, Backer V, Heitmann BL. Neonatal Vitamin D Status and Risk of Asthma in Childhood: Results from the D-Tect Study. Nutrients. 2020; 12(3):842.

Chicago/Turabian Style

Thorsteinsdottir, Fanney, Isabel Cardoso, Amélie Keller, Maria Stougaard, Peder Frederiksen, Arieh S. Cohen, Ekaterina Maslova, Ramune Jacobsen, Vibeke Backer, and Berit L. Heitmann 2020. "Neonatal Vitamin D Status and Risk of Asthma in Childhood: Results from the D-Tect Study" Nutrients 12, no. 3: 842.

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