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Open AccessArticle

The Effect of DHA Supplementation on Cognition in Patients with Bipolar Disorder: An Exploratory Randomized Control Trial

1
Fondazione IRCCS Ca’ Granda-Ospedale Maggiore Policlinico, Department of Neurosciences and Mental Health, 20122 Milan, Italy
2
Department of Pathophysiology and Transplantation, University of Milan, 20122 Milan, Italy
3
Department of Statistical Sciences, University of Padua, 35100 Padua, Italy
4
Department of Developmental Psychology and Socialization, University of Padua, 35100 Padua, Italy
5
Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy
6
SINGEP (Italian Society of pediatric Gastroenterology, Hepatology and Nutrition), Via Libero Temolo 4 (Torre U8), 20126 Milan, Italy
7
Neurologic Clinic, Fondazione IRCCS Istituto neurologico Carlo Besta, 20133 Milan, Italy
8
Fondazione IRCCS Ca’ Granda-Ospedale Maggiore Policlinico, Pediatric Nephrology, Dialysis and Transplant Unit, 20122 Milan, Italy
9
Pediatric Intermediate Care Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2020, 12(3), 708; https://doi.org/10.3390/nu12030708
Received: 10 January 2020 / Revised: 24 February 2020 / Accepted: 29 February 2020 / Published: 6 March 2020
(This article belongs to the Special Issue Nutrients and Brain across the Lifespan)
Bipolar disorder (BD) is a severe mental disorder with a wide range of cognitive deficits, both in the euthymic and acute phase of the disease. Interestingly, in recent years, there has been a growing interest in investigating the impact of ω-3 polyunsaturated fatty acids on cognition in BD. In this context, the aim of this study is to evaluate the effect of docosahexaenoic acid (C22:6 ω-3, DHA) supplementation on cognitive performances in euthymic BD patients. This is an exploratory, single-centre, double-blind randomized controlled trial evaluating 12 weeks DHA supplementation (1250 mg daily) vs. a placebo (corn oil) in 31 euthymic BD patients compared to 15 healthy controls (HCs) on cognitive functions, assessed by the Brief Assessment of Cognition in Affective Disorder (BAC-A). Plasma levels of DHA were measured. After 12 weeks of treatment, no significant group differences were observed in all neuropsychological tests between the four groups, except for the emotion inhibition test, where HCs with DHA had higher scores compared to either BD with DHA (z = 3.9, p = 0.003) or BD with placebo (t = 3.7, p = 0.005). Although our results showed that DHA could be effective for ameliorating cognition in healthy subjects, future studies are still needed to clarify the impact of DHA on cognition in BD. View Full-Text
Keywords: bipolar disorder; docosahexaenoic acid; ω-3 long chain polyunsaturated fatty acids; cognitive functions bipolar disorder; docosahexaenoic acid; ω-3 long chain polyunsaturated fatty acids; cognitive functions
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MDPI and ACS Style

Ciappolino, V.; DelVecchio, G.; Prunas, C.; Andreella, A.; Finos, L.; Caletti, E.; Siri, F.; Mazzocchi, A.; Botturi, A.; Turolo, S.; Agostoni, C.; Brambilla, P. The Effect of DHA Supplementation on Cognition in Patients with Bipolar Disorder: An Exploratory Randomized Control Trial. Nutrients 2020, 12, 708.

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