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A 12-Week-Long Intake of Bilberry Extract (Vaccinium myrtillus L.) Improved Objective Findings of Ciliary Muscle Contraction of the Eye: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Comparison Trial

1
Research Department, Omnica Co., Ltd, 4-21-7 Itabashi, Itabashi Ward, Tokyo 173-0004, Japan
2
Department of Ophthalmology, Health Sciences University of Hokkaido, Sapporo 002-8072, Japan
*
Authors to whom correspondence should be addressed.
Nutrients 2020, 12(3), 600; https://doi.org/10.3390/nu12030600
Received: 27 January 2020 / Revised: 21 February 2020 / Accepted: 22 February 2020 / Published: 25 February 2020
(This article belongs to the Section Phytochemicals and Human Health)
A 12-week-long randomized, double-blind, placebo-controlled, parallel-group comparison trial was conducted to determine the effects of long-term standardized bilberry extract (SBE) intake on tonic accommodation of ciliary muscle caused by visual display terminal (VDT) tasks. This study was compliant with the accordance with CONSORT 2010 statement. A total of 109 healthy adult men and women aged 20–60 years were recruited and randomized into SBE and placebo groups. The subjects in the SBE and placebo groups were administered 240 mg of SBE and placebo, respectively, once daily for 12 weeks. Tests were performed before and after VDT tasks at week 0, 4, 8, and 12; high-frequency component (HFC)-1 value was the evaluation outcome. Results showed that post-load HFC-1 values at weeks 8 and 12 were significantly improved in the SBE group than in the placebo group (p = 0.014 and 0.017, respectively). This study shows that oral consumption of 240 mg SBE extract for 12 weeks relieves the tonic accommodation of the ciliary muscle caused by VDT tasks and near-vision tasks. View Full-Text
Keywords: bilberry; asthenopia; clinical trial; accommodation; refraction; accommodative microfluctuation bilberry; asthenopia; clinical trial; accommodation; refraction; accommodative microfluctuation
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MDPI and ACS Style

Kosehira, M.; Machida, N.; Kitaichi, N. A 12-Week-Long Intake of Bilberry Extract (Vaccinium myrtillus L.) Improved Objective Findings of Ciliary Muscle Contraction of the Eye: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Comparison Trial. Nutrients 2020, 12, 600. https://doi.org/10.3390/nu12030600

AMA Style

Kosehira M, Machida N, Kitaichi N. A 12-Week-Long Intake of Bilberry Extract (Vaccinium myrtillus L.) Improved Objective Findings of Ciliary Muscle Contraction of the Eye: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Comparison Trial. Nutrients. 2020; 12(3):600. https://doi.org/10.3390/nu12030600

Chicago/Turabian Style

Kosehira, Marie, Naomichi Machida, and Nobuyoshi Kitaichi. 2020. "A 12-Week-Long Intake of Bilberry Extract (Vaccinium myrtillus L.) Improved Objective Findings of Ciliary Muscle Contraction of the Eye: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Comparison Trial" Nutrients 12, no. 3: 600. https://doi.org/10.3390/nu12030600

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