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Gut Microbiota Profile of Obese Diabetic Women Submitted to Roux-en-Y Gastric Bypass and Its Association with Food Intake and Postoperative Diabetes Remission

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Department of Gastroenterology, FMUSP, School of Medicine, University of São Paulo, Digestive Surgery Discipline (LIM 35), São Paulo 01246-903, Brazil
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Sorbonne Universités, IRD, Unité de Modélisation Mathématique et Informatique des Systèmes Complexes (UMMISCO), F-93143 Bondy, France
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Institute of Cardiometabolism and Nutrition (ICAN) Integromics Team, Pitié-Salpêtrière Hospital, 75013 Paris, France
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Assistance Publique Hôpitaux de Paris, Nutrition Department, Pitié-Salpêtrière Hospital, 75013 Paris, France
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Sorbonne Université, INSERM, NutriOmics Research Unit, 75013 Paris, France
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Université Paris-Saclay, INRA, MetaGenoPolis, AgroParisTech, MICALIS, 78350 Jouy-en-Josas, France
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Department of Clinical Analysis and Toxicology, School of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-000, Brazil
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Medical Genomics Laboratory, CIPE/A.C. Camargo Cancer Center, São Paulo 01525-001, Brazil
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Laboratory of Neurosciences (LIM-27) Alzira Denise Hertzog Silva, Institute of Psychiatry, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo 05403-010, Brazil
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Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo 05508-220, Brazil
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Biocomplexity Institute of Virginia Tech, Blacksburg, VA 24061, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally.
Nutrients 2020, 12(2), 278; https://doi.org/10.3390/nu12020278
Received: 7 October 2019 / Revised: 7 December 2019 / Accepted: 17 December 2019 / Published: 21 January 2020
Gut microbiota composition is influenced by environmental factors and has been shown to impact body metabolism. Objective: To assess the gut microbiota profile before and after Roux-en-Y gastric bypass (RYGB) and the correlation with food intake and postoperative type 2 diabetes remission (T2Dr). Design: Gut microbiota profile from obese diabetic women was evaluated before (n = 25) and 3 (n = 20) and 12 months (n = 14) after RYGB, using MiSeq Illumina-based V4 bacterial 16S rRNA gene profiling. Data on food intake (7-day record) and T2Dr (American Diabetes Association (ADA) criteria) were recorded. Results: Preoperatively, the abundance of five bacteria genera differed between patients with (57%) and without T2Dr (p < 0.050). Preoperative gut bacteria genus signature was able to predict the T2Dr status with 0.94 accuracy ROC curve (receiver operating characteristic curve). Postoperatively (vs. preoperative), the relative abundance of some gut bacteria genera changed, the gut microbial richness increased, and the Firmicutes to Bacteroidetes ratio (rFB) decreased (p < 0.05) regardless of T2Dr. Richness levels was correlated with dietary profile pre and postoperatively, mainly displaying positive and inverse correlations with fiber and lipid intakes, respectively (p < 0.05). Conclusions: Gut microbiota profile was influenced by RYGB and correlated with diet and T2Dr preoperatively, suggesting the possibility to assess its composition to predict postoperative T2Dr. View Full-Text
Keywords: bariatric surgery; type 2 diabetes mellitus; gut microbiota bariatric surgery; type 2 diabetes mellitus; gut microbiota
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MDPI and ACS Style

Al Assal, K.; Prifti, E.; Belda, E.; Sala, P.; Clément, K.; Dao, M.-C.; Doré, J.; Levenez, F.; Taddei, C.R.; Fonseca, D.C.; Rocha, I.M.; Balmant, B.D.; Thomas, A.M.; Santo, M.A.; Dias-Neto, E.; Setubal, J.C.; Zucker, J.-D.; Belarmino, G.; Torrinhas, R.S.; Waitzberg, D.L. Gut Microbiota Profile of Obese Diabetic Women Submitted to Roux-en-Y Gastric Bypass and Its Association with Food Intake and Postoperative Diabetes Remission. Nutrients 2020, 12, 278. https://doi.org/10.3390/nu12020278

AMA Style

Al Assal K, Prifti E, Belda E, Sala P, Clément K, Dao M-C, Doré J, Levenez F, Taddei CR, Fonseca DC, Rocha IM, Balmant BD, Thomas AM, Santo MA, Dias-Neto E, Setubal JC, Zucker J-D, Belarmino G, Torrinhas RS, Waitzberg DL. Gut Microbiota Profile of Obese Diabetic Women Submitted to Roux-en-Y Gastric Bypass and Its Association with Food Intake and Postoperative Diabetes Remission. Nutrients. 2020; 12(2):278. https://doi.org/10.3390/nu12020278

Chicago/Turabian Style

Al Assal, Karina, Edi Prifti, Eugeni Belda, Priscila Sala, Karine Clément, Maria-Carlota Dao, Joel Doré, Florence Levenez, Carla R. Taddei, Danielle C. Fonseca, Ilanna M. Rocha, Bianca D. Balmant, Andrew M. Thomas, Marco A. Santo, Emmanuel Dias-Neto, João C. Setubal, Jean-Daniel Zucker, Giliane Belarmino, Raquel S. Torrinhas, and Dan L. Waitzberg 2020. "Gut Microbiota Profile of Obese Diabetic Women Submitted to Roux-en-Y Gastric Bypass and Its Association with Food Intake and Postoperative Diabetes Remission" Nutrients 12, no. 2: 278. https://doi.org/10.3390/nu12020278

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