Next Article in Journal
Psychobiotics: Mechanisms of Action, Evaluation Methods and Effectiveness in Applications with Food Products
Previous Article in Journal
Passiflora incarnata in Neuropsychiatric Disorders—A Systematic Review
nutrients-logo
Article Menu
Article

Mediterranean Diet Decreases the Initiation of Use of Vitamin K Epoxide Reductase Inhibitors and Their Associated Cardiovascular Risk: A Randomized Controlled Trial

1
Cardiovascular Risk, Nutrition and Aging Research Group, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), 08036 Barcelona, Spain
2
Department of Medicine, Faculty of Medicine and Health Sciences, University of Barcelona, 08036 Barcelona, Spain
3
Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain
4
Faculty of Pharmacy and Food Science, Universitat de Barcelona, 08028 Barcelona, Spain
5
Cardiovascular Risk and Nutrition Research Group, Hospital del Mar Medical Research Institute (IMIM), 08003 Barcelona, Spain
6
Unitat de Nutrició Humana, Departament de Bioquimica i Biotecnologia, Hospital Universitari Sant Joan de Reus, Universitat Rovira i Virgili, 43201 Reus, Spain
7
Institut d′Investigació Pere Virgili (IISPV), 43204 Reus, Spain
8
Department of Nutrition, Food Science and Gastronomy, XaRTA, INSA, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain
9
Lipids and Vascular Risk Unit, Internal Medicine Service, Hospital Universitario de Bellvitge, 08907 L’Hospitalet de Llobregat, Spain
10
Department of Preventive Medicine and Public Health, Universidad de Navarra, 31008 Pamplona, Spain
11
Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA 02115, USA
12
Department of Preventive Medicine, Universidad de Valencia, 46100 Valencia, Spain
13
Department of Family Medicine, Research Unit, Distrito Sanitario Atención Primaria Sevilla, 41013 Sevilla, Spain
14
Department of Preventive Medicine and Public Health, Universidad de Málaga, 29071 Málaga, Spain
15
Bioaraba Health Research Institute, Osakidetza Basque Health Service, Araba University Hospital, University of the Basque Country UPV/EHU, 01009 Vitoria-Gasteiz, Spain
16
Health Research Institute of the Balearic Islands (IdISBa), Hospital Son Espases, 07120 Palma de Mallorca, Spain
17
Instituto de Investigaciones Biomédicas y Sanitarias, Universidad de Las Palmas de Gran Canaria, 35016 Las Palmas, Spain
18
Centro Hospitalario Universitario Insular Materno Infantil (CHUIMI), Servicio Canario de Salud, 35016 Las Palmas, Spain
19
Internal Medicine Service, Hospital Clínic, 08036 Barcelona, Spain
20
Department of Endocrinology and Nutrition, Complejo Hospitalario de Navarra, 31008 Pamplona, Spain
21
Lipid Clinic, Endocrinology and Nutrition Service, Hospital Clínic, 08036 Barcelona, Spain
22
Blanquerna School of Health Sciences, Universitat Ramon Llull, 08025 Barcelona, Spain
*
Author to whom correspondence should be addressed.
Both authors contributed equally to this work.
Nutrients 2020, 12(12), 3895; https://doi.org/10.3390/nu12123895
Received: 23 November 2020 / Revised: 12 December 2020 / Accepted: 16 December 2020 / Published: 19 December 2020
(This article belongs to the Section Nutritional Epidemiology)
Our aim is to assess whether following a Mediterranean Diet (MedDiet) decreases the risk of initiating antithrombotic therapies and the cardiovascular risk associated with its use in older individuals at high cardiovascular risk. We evaluate whether participants of the PREvención con DIeta MEDiterránea (PREDIMED) study allocated to a MedDiet enriched in extra-virgin olive oil or nuts (versus a low-fat control intervention) disclose differences in the risk of initiation of: (1) vitamin K epoxide reductase inhibitors (acenocumarol/warfarin; n = 6772); (2) acetylsalicylic acid as antiplatelet agent (n = 5662); and (3) other antiplatelet drugs (cilostazol/clopidogrel/dipyridamole/ditazol/ticlopidine/triflusal; n = 6768). We also assess whether MedDiet modifies the association between the antithrombotic drug baseline use and incident cardiovascular events. The MedDiet intervention enriched with extra-virgin olive oil decreased the risk of initiating the use of vitamin K epoxide reductase inhibitors relative to control diet (HR: 0.68 [0.46–0.998]). Their use was also more strongly associated with an increased risk of cardiovascular disease in participants not allocated to MedDiet interventions (HRcontrol diet: 4.22 [1.92–9.30], HRMedDiets: 1.71 [0.83–3.52], p-interaction = 0.052). In conclusion, in an older population at high cardiovascular risk, following a MedDiet decreases the initiation of antithrombotic therapies and the risk of suffering major cardiovascular events among users of vitamin K epoxide reductase inhibitors. View Full-Text
Keywords: Mediterranean Diet; randomized controlled trials; prevention; 4-hydroxycoumarins; platelet aggregation inhibitors Mediterranean Diet; randomized controlled trials; prevention; 4-hydroxycoumarins; platelet aggregation inhibitors
Show Figures

Figure 1

MDPI and ACS Style

Castro-Barquero, S.; Ribó-Coll, M.; Lassale, C.; Tresserra-Rimbau, A.; Castañer, O.; Pintó, X.; Martínez-González, M.Á.; Sorlí, J.V.; Salas-Salvadó, J.; Lapetra, J.; Gómez-Gracia, E.; Alonso-Gómez, Á.M.; Fiol, M.; Serra-Majem, L.; Sacanella, E.; Basterra-Gortari, F.J.; Portolés, O.; Babio, N.; Cofán, M.; Ros, E.; Estruch, R.; Hernáez, Á. Mediterranean Diet Decreases the Initiation of Use of Vitamin K Epoxide Reductase Inhibitors and Their Associated Cardiovascular Risk: A Randomized Controlled Trial. Nutrients 2020, 12, 3895. https://doi.org/10.3390/nu12123895

AMA Style

Castro-Barquero S, Ribó-Coll M, Lassale C, Tresserra-Rimbau A, Castañer O, Pintó X, Martínez-González MÁ, Sorlí JV, Salas-Salvadó J, Lapetra J, Gómez-Gracia E, Alonso-Gómez ÁM, Fiol M, Serra-Majem L, Sacanella E, Basterra-Gortari FJ, Portolés O, Babio N, Cofán M, Ros E, Estruch R, Hernáez Á. Mediterranean Diet Decreases the Initiation of Use of Vitamin K Epoxide Reductase Inhibitors and Their Associated Cardiovascular Risk: A Randomized Controlled Trial. Nutrients. 2020; 12(12):3895. https://doi.org/10.3390/nu12123895

Chicago/Turabian Style

Castro-Barquero, Sara, Margarita Ribó-Coll, Camille Lassale, Anna Tresserra-Rimbau, Olga Castañer, Xavier Pintó, Miguel Á. Martínez-González, José V. Sorlí, Jordi Salas-Salvadó, José Lapetra, Enrique Gómez-Gracia, Ángel M. Alonso-Gómez, Miquel Fiol, Lluis Serra-Majem, Emilio Sacanella, Francisco J. Basterra-Gortari, Olga Portolés, Nancy Babio, Montserrat Cofán, Emilio Ros, Ramón Estruch, and Álvaro Hernáez. 2020. "Mediterranean Diet Decreases the Initiation of Use of Vitamin K Epoxide Reductase Inhibitors and Their Associated Cardiovascular Risk: A Randomized Controlled Trial" Nutrients 12, no. 12: 3895. https://doi.org/10.3390/nu12123895

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop