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Article

Acrylamide–Hemoglobin Adduct Levels in a Japanese Population and Comparison with Acrylamide Exposure Assessed by the Duplicated Method or a Food Frequency Questionnaire

1
School of Life and Environmental Science, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan
2
Graduate School of Engineering, Kyoto University, Yoshida Honmachi, Sakyo-ku, Kyoto 606-8501, Japan
3
Division of Epidemiology, Center for Public Health Sciences, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
4
Center for Health and Environmental Risk Research, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 305-8506, Japan
5
Department of Public Health, Faculty of Nutritional Science, Sagami Women’s University, 2-1-1 Bunkyo, Minami-ku, Sagamihara, Kanagawa 252-0383, Japan
6
Department of Environmental Medicine and Population Sciences, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
*
Author to whom correspondence should be addressed.
Principal investigator.
Nutrients 2020, 12(12), 3863; https://doi.org/10.3390/nu12123863
Received: 26 November 2020 / Revised: 15 December 2020 / Accepted: 16 December 2020 / Published: 17 December 2020
(This article belongs to the Special Issue The Association between Dietary Acrylamide Exposure and Cancer Risk)
The levels of hemoglobin adducts of acrylamide (AA–Hb), a biomarker of acrylamide exposure, have not been reported for Japanese subjects. Herein, we determined the AA–Hb levels in a Japanese population and compared them with the estimated dietary intake from the duplicate diet method (DM) and a food frequency questionnaire (FFQ). One-day DM samples, FFQ, and blood samples were collected from 89 participants and analyzed for acrylamide. AA–Hb was analyzed using liquid chromatography tandem mass spectrometry and the N-alkyl Edman method. Participants were divided into tertiles of estimated acrylamide intake and geometric means (GMs) of AA–Hb adjusted for sex and smoking status. A stratified analysis according to smoking status was also performed. The average AA–Hb levels for all participants, never, past, and current smokers were 46, 38, 65, and 86 pmol/g Hb, respectively. GMs of AA–Hb levels in all participants were significantly associated with tertiles of estimated acrylamide intake from DM (p for trend = 0.02) and FFQ (p for trend = 0.04), although no association with smokers was observed. AA–Hb levels reflected smoking status, which were similar to values reported in Western populations, and they were associated with estimated dietary intake of acrylamide when adjusted for sex and smoking status. View Full-Text
Keywords: acrylamide; hemoglobin adducts of acrylamide; duplicate method; food frequency questionnaire acrylamide; hemoglobin adducts of acrylamide; duplicate method; food frequency questionnaire
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MDPI and ACS Style

Yamamoto, J.; Ishihara, J.; Matsui, Y.; Matsuda, T.; Kotemori, A.; Zheng, Y.; Nakajima, D.; Terui, M.; Shinohara, A.; Adachi, S.; Kawahara, J.; Sobue, T. Acrylamide–Hemoglobin Adduct Levels in a Japanese Population and Comparison with Acrylamide Exposure Assessed by the Duplicated Method or a Food Frequency Questionnaire. Nutrients 2020, 12, 3863. https://doi.org/10.3390/nu12123863

AMA Style

Yamamoto J, Ishihara J, Matsui Y, Matsuda T, Kotemori A, Zheng Y, Nakajima D, Terui M, Shinohara A, Adachi S, Kawahara J, Sobue T. Acrylamide–Hemoglobin Adduct Levels in a Japanese Population and Comparison with Acrylamide Exposure Assessed by the Duplicated Method or a Food Frequency Questionnaire. Nutrients. 2020; 12(12):3863. https://doi.org/10.3390/nu12123863

Chicago/Turabian Style

Yamamoto, Junpei, Junko Ishihara, Yasuto Matsui, Tomonari Matsuda, Ayaka Kotemori, Yazhi Zheng, Daisuke Nakajima, Miho Terui, Akiko Shinohara, Shuichi Adachi, Junko Kawahara, and Tomotaka Sobue. 2020. "Acrylamide–Hemoglobin Adduct Levels in a Japanese Population and Comparison with Acrylamide Exposure Assessed by the Duplicated Method or a Food Frequency Questionnaire" Nutrients 12, no. 12: 3863. https://doi.org/10.3390/nu12123863

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