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Open AccessFeature PaperReview

Magnesium Status and Stress: The Vicious Circle Concept Revisited

1
Plateforme d’Investigation Clinique/CIC Inserm 1405, University Hospital CHU, 63000 Clermont-Ferrand, France
2
INRAE, UNH, Unité de Nutrition Humaine, Université Clermont Auvergne, 63001 Clermont-Ferrand, France
3
Independent Regulatory Board for Auditors (IRBA), 91220 Bretigny-sur-Orge, France
4
Department of Psychiatry, Warsaw Medical University, 02-091 Warsaw, Poland
5
Department of General Medicine, The Yaroslavl State Medical University Institute of Postgraduate Education, 150000 Yaroslavl, Russia
6
Medical Affairs Department, Consumer HealthCare, Sanofi, Gentilly, 94250 Paris, France
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(12), 3672; https://doi.org/10.3390/nu12123672
Received: 11 November 2020 / Revised: 24 November 2020 / Accepted: 25 November 2020 / Published: 28 November 2020
(This article belongs to the Special Issue Magnesium in Human Health and Disease)
Magnesium deficiency and stress are both common conditions among the general population, which, over time, can increase the risk of health consequences. Numerous studies, both in pre-clinical and clinical settings, have investigated the interaction of magnesium with key mediators of the physiological stress response, and demonstrated that magnesium plays an inhibitory key role in the regulation and neurotransmission of the normal stress response. Furthermore, low magnesium status has been reported in several studies assessing nutritional aspects in subjects suffering from psychological stress or associated symptoms. This overlap in the results suggests that stress could increase magnesium loss, causing a deficiency; and in turn, magnesium deficiency could enhance the body’s susceptibility to stress, resulting in a magnesium and stress vicious circle. This review revisits the magnesium and stress vicious circle concept, first introduced in the early 1990s, in light of recent available data.
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Keywords: stress; magnesium; hypomagnesemia; magnesium deficiency; vicious circle; dietary intake; magnesium supplementation stress; magnesium; hypomagnesemia; magnesium deficiency; vicious circle; dietary intake; magnesium supplementation
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MDPI and ACS Style

Pickering, G.; Mazur, A.; Trousselard, M.; Bienkowski, P.; Yaltsewa, N.; Amessou, M.; Noah, L.; Pouteau, E. Magnesium Status and Stress: The Vicious Circle Concept Revisited. Nutrients 2020, 12, 3672. https://doi.org/10.3390/nu12123672

AMA Style

Pickering G, Mazur A, Trousselard M, Bienkowski P, Yaltsewa N, Amessou M, Noah L, Pouteau E. Magnesium Status and Stress: The Vicious Circle Concept Revisited. Nutrients. 2020; 12(12):3672. https://doi.org/10.3390/nu12123672

Chicago/Turabian Style

Pickering, Gisèle; Mazur, André; Trousselard, Marion; Bienkowski, Przemyslaw; Yaltsewa, Natalia; Amessou, Mohamed; Noah, Lionel; Pouteau, Etienne. 2020. "Magnesium Status and Stress: The Vicious Circle Concept Revisited" Nutrients 12, no. 12: 3672. https://doi.org/10.3390/nu12123672

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Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

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