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Open AccessFeature PaperReview

Magnesium Status and Stress: The Vicious Circle Concept Revisited

Plateforme d’Investigation Clinique/CIC Inserm 1405, University Hospital CHU, 63000 Clermont-Ferrand, France
INRAE, UNH, Unité de Nutrition Humaine, Université Clermont Auvergne, 63001 Clermont-Ferrand, France
Independent Regulatory Board for Auditors (IRBA), 91220 Bretigny-sur-Orge, France
Department of Psychiatry, Warsaw Medical University, 02-091 Warsaw, Poland
Department of General Medicine, The Yaroslavl State Medical University Institute of Postgraduate Education, 150000 Yaroslavl, Russia
Medical Affairs Department, Consumer HealthCare, Sanofi, Gentilly, 94250 Paris, France
Author to whom correspondence should be addressed.
Nutrients 2020, 12(12), 3672;
Received: 11 November 2020 / Revised: 24 November 2020 / Accepted: 25 November 2020 / Published: 28 November 2020
(This article belongs to the Special Issue Magnesium in Human Health and Disease)
Magnesium deficiency and stress are both common conditions among the general population, which, over time, can increase the risk of health consequences. Numerous studies, both in pre-clinical and clinical settings, have investigated the interaction of magnesium with key mediators of the physiological stress response, and demonstrated that magnesium plays an inhibitory key role in the regulation and neurotransmission of the normal stress response. Furthermore, low magnesium status has been reported in several studies assessing nutritional aspects in subjects suffering from psychological stress or associated symptoms. This overlap in the results suggests that stress could increase magnesium loss, causing a deficiency; and in turn, magnesium deficiency could enhance the body’s susceptibility to stress, resulting in a magnesium and stress vicious circle. This review revisits the magnesium and stress vicious circle concept, first introduced in the early 1990s, in light of recent available data.
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Keywords: stress; magnesium; hypomagnesemia; magnesium deficiency; vicious circle; dietary intake; magnesium supplementation stress; magnesium; hypomagnesemia; magnesium deficiency; vicious circle; dietary intake; magnesium supplementation
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MDPI and ACS Style

Pickering, G.; Mazur, A.; Trousselard, M.; Bienkowski, P.; Yaltsewa, N.; Amessou, M.; Noah, L.; Pouteau, E. Magnesium Status and Stress: The Vicious Circle Concept Revisited. Nutrients 2020, 12, 3672.

AMA Style

Pickering G, Mazur A, Trousselard M, Bienkowski P, Yaltsewa N, Amessou M, Noah L, Pouteau E. Magnesium Status and Stress: The Vicious Circle Concept Revisited. Nutrients. 2020; 12(12):3672.

Chicago/Turabian Style

Pickering, Gisèle; Mazur, André; Trousselard, Marion; Bienkowski, Przemyslaw; Yaltsewa, Natalia; Amessou, Mohamed; Noah, Lionel; Pouteau, Etienne. 2020. "Magnesium Status and Stress: The Vicious Circle Concept Revisited" Nutrients 12, no. 12: 3672.

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