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Article

Ultra-Marathon-Induced Increase in Serum Levels of Vitamin D Metabolites: A Double-Blind Randomized Controlled Trial

1
Department of Gymnastics and Dance, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland
2
Institute of Physical Education, Kazimierz Wielki University, 85-064 Bydgoszcz, Poland
3
Department of Histology, Medical University of Gdańsk, 80-211 Gdansk, Poland
4
Masdiag Sp. z o.o. Company, 01-882 Warsaw, Poland
5
Chair of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University in Toruń, 87-100 Toruń, Poland
6
Department of Bioenergetics and Physiology of Exercise, Medical University of Gdansk, 80-210 Gdansk, Poland
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(12), 3629; https://doi.org/10.3390/nu12123629
Received: 20 October 2020 / Revised: 19 November 2020 / Accepted: 23 November 2020 / Published: 25 November 2020
Purpose: While an increasing number of studies demonstrate the importance of vitamin D for athletic performance, the effects of any type of exercise on vitamin D metabolism are poorly characterized. We aimed to identify the responses of some vitamin D metabolites to ultra-marathon runs. Methods: A repeated-measures design was implemented, in which 27 amateur runners were assigned into two groups: those who received a single dose of vitamin D3 (150,000 IU) 24 h before the start of the marathon (n = 13) and those (n = 14) who received a placebo. Blood samples were collected 24 h before, immediately after, and 24 h after the run. Results: In both groups of runners, serum 25(OH)D3, 24,25(OH)2D3, and 3-epi-25(OH)D3 levels significantly increased by 83%, 63%, and 182% after the ultra-marathon, respectively. The increase was most pronounced in the vitamin D group. Body mass and fat mass significantly decreased after the run in both groups. Conclusions: Ultra-marathon induces the mobilization of vitamin D into the blood. Furthermore, the 24,25(OH)2D3 and 3-epi-25(OH)D3 increases imply that the exercise stimulates vitamin D metabolism. View Full-Text
Keywords: endurance exercise; 3-epi-25(OH)D3; 24,25(OH)2D3; 25(OH)D3 endurance exercise; 3-epi-25(OH)D3; 24,25(OH)2D3; 25(OH)D3
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MDPI and ACS Style

Mieszkowski, J.; Stankiewicz, B.; Kochanowicz, A.; Niespodziński, B.; Kowalik, T.; Żmijewski, M.A.; Kowalski, K.; Rola, R.; Bieńkowski, T.; Antosiewicz, J. Ultra-Marathon-Induced Increase in Serum Levels of Vitamin D Metabolites: A Double-Blind Randomized Controlled Trial. Nutrients 2020, 12, 3629. https://doi.org/10.3390/nu12123629

AMA Style

Mieszkowski J, Stankiewicz B, Kochanowicz A, Niespodziński B, Kowalik T, Żmijewski MA, Kowalski K, Rola R, Bieńkowski T, Antosiewicz J. Ultra-Marathon-Induced Increase in Serum Levels of Vitamin D Metabolites: A Double-Blind Randomized Controlled Trial. Nutrients. 2020; 12(12):3629. https://doi.org/10.3390/nu12123629

Chicago/Turabian Style

Mieszkowski, Jan, Błażej Stankiewicz, Andrzej Kochanowicz, Bartłomiej Niespodziński, Tomasz Kowalik, Michał A. Żmijewski, Konrad Kowalski, Rafał Rola, Tomasz Bieńkowski, and Jędrzej Antosiewicz. 2020. "Ultra-Marathon-Induced Increase in Serum Levels of Vitamin D Metabolites: A Double-Blind Randomized Controlled Trial" Nutrients 12, no. 12: 3629. https://doi.org/10.3390/nu12123629

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