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Complex Enterally Tube-Fed Community Patients Display Stable Tolerance, Improved Compliance and Better Achieve Energy and Protein Targets with a High-Energy, High-Protein Peptide-Based Enteral Tube Feed: Results from a Multi-Centre Pilot Study

1
Medical Affairs, Nutricia, Trowbridge BA14 0XQ, UK
2
Royal Surrey County Hospital NHS Foundation Trust, Guildford GU2 7XX, UK
3
Calderdale and Huddersfield NHS Foundation Trust, Huddersfield HD3 3EA, UK
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Gloucestershire Hospitals NHS Foundation Trust, Gloucestershire GL53 7AN, UK
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Somerset NHS Foundation Trust, Somerset TA6 4RN, UK
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University Hospitals Bristol and Weston NHS Foundation Trust, Bristol BS1 3NU, UK
7
Aneurin Bevan University Health Board, Newport NP18 3XQ, UK
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North Tees and Hartlepool NHS Foundation Trust, Stockton on Tees TS19 8PE, UK
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Northumbria Healthcare NHS Foundation Trust, North Shields NE29 8NH, UK
10
University Hospitals of Derby and Burton NHS Foundation Trust, Derby DE22 3NE, UK
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University Hospitals Birmingham NHS Foundation Trust, Birmingham B15 2GW, UK
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NHS Greater Glasgow and Clyde, Glasgow G12 0XH, UK
13
Faculty of Medicine, University of Southampton, Southampton SO17 1BJ, UK
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(11), 3538; https://doi.org/10.3390/nu12113538
Received: 1 September 2020 / Revised: 9 November 2020 / Accepted: 12 November 2020 / Published: 18 November 2020
(This article belongs to the Special Issue Advances in Enteral Nutrition)
This pilot study evaluated a high-energy, high-protein, peptide-based, (medium-chain triglycerides) MCT-containing enteral tube feed (Nutrison Peptisorb Plus HEHP®, Nutricia Ltd., Trowbridge, BA14 0XQ, UK.) containing 1.5 kcal/mL and 7.5 g protein/100 mL. Fifteen community-based, enterally tube-fed adults (42 (SD 16.3) years) received the intervention feed daily for 28 days, with gastrointestinal tolerance, compliance and nutrient intake assessed at baseline and after the intervention period. Incidence and intensity of constipation (p = 0.496), nausea (p = 1.000), abdominal pain (p = 0.366) and bloating (p = 0.250) remained statistically unchanged, yet the incidence and intensity of diarrhoea improved significantly after receiving the intervention feed (Z = −2.271, p = 0.023). Compliance with the intervention feed was significantly greater compared to the patient’s baseline regimens (99% vs. 87%, p = 0.038). Compared to baseline, use of the intervention feed enabled patients to significantly increase total energy (1676 kcal/day (SD 449) to 1884 kcal/day (SD 537), p = 0.039) and protein intake (73 g/day (SD 17) to 89 g/day (SD 23), p = 0.001), allowing patients to better achieve energy (from 88% to 99%, p = 0.038) and protein (from 101% to 121%, p < 0.001) requirements. This pilot study demonstrates that a high-energy, high-protein, peptide-based, MCT-containing enteral tube feed maintains gastrointestinal tolerance and improves compliance, energy and protein intake in complex, enterally tube-fed, community-based adult patients, though more work is recommended to confirm this. View Full-Text
Keywords: enteral nutrition; gastrointestinal tolerance; peptide; energy; protein; compliance enteral nutrition; gastrointestinal tolerance; peptide; energy; protein; compliance
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MDPI and ACS Style

Green, B.; Sorensen, K.; Phillips, M.; Green, L.; Watson, R.; McCallum, A.; Brook, S.; Oldham, S.; Barry, M.; Tomlinson, L.; Williams, A.; Crease, S.; Wills, C.; Talbot, R.; Thomas, R.; Barker, J.; Owen, A.; Davies, J.; Robinson, C.; Lumsdon, A.; Morris, S.; McMurray, C.; Cunningham, N.; Miller, L.; Day, C.; Stanley, K.; Price, S.; Duff, S.; Julian, A.; Thomas, J.; Fleming, C.-A.; Hubbard, G.; Stratton, R. Complex Enterally Tube-Fed Community Patients Display Stable Tolerance, Improved Compliance and Better Achieve Energy and Protein Targets with a High-Energy, High-Protein Peptide-Based Enteral Tube Feed: Results from a Multi-Centre Pilot Study. Nutrients 2020, 12, 3538. https://doi.org/10.3390/nu12113538

AMA Style

Green B, Sorensen K, Phillips M, Green L, Watson R, McCallum A, Brook S, Oldham S, Barry M, Tomlinson L, Williams A, Crease S, Wills C, Talbot R, Thomas R, Barker J, Owen A, Davies J, Robinson C, Lumsdon A, Morris S, McMurray C, Cunningham N, Miller L, Day C, Stanley K, Price S, Duff S, Julian A, Thomas J, Fleming C-A, Hubbard G, Stratton R. Complex Enterally Tube-Fed Community Patients Display Stable Tolerance, Improved Compliance and Better Achieve Energy and Protein Targets with a High-Energy, High-Protein Peptide-Based Enteral Tube Feed: Results from a Multi-Centre Pilot Study. Nutrients. 2020; 12(11):3538. https://doi.org/10.3390/nu12113538

Chicago/Turabian Style

Green, Benjamin, Katy Sorensen, Mary Phillips, Lisa Green, Rachel Watson, Adrienne McCallum, Sarah Brook, Siobhan Oldham, Michelle Barry, Lyndsey Tomlinson, Alice Williams, Sam Crease, Carrie Wills, Rose Talbot, Rourke Thomas, Julie Barker, Annalisa Owen, Judith Davies, Carys Robinson, Anna Lumsdon, Samm Morris, Chloé McMurray, Nicola Cunningham, Lily Miller, Carolyn Day, Kristina Stanley, Susan Price, Susan Duff, Anna Julian, Jennifer Thomas, Carole-Anne Fleming, Gary Hubbard, and Rebecca Stratton. 2020. "Complex Enterally Tube-Fed Community Patients Display Stable Tolerance, Improved Compliance and Better Achieve Energy and Protein Targets with a High-Energy, High-Protein Peptide-Based Enteral Tube Feed: Results from a Multi-Centre Pilot Study" Nutrients 12, no. 11: 3538. https://doi.org/10.3390/nu12113538

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