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Article

Dietary Inflammatory Index during Pregnancy and the Risk of Intrapartum Fetal Asphyxia: The Japan Environment and Children’s Study

1
Fukushima Regional Center for the Japan Environmental and Children’s Study, 1 Hikarigaoka, Fukushima 960-1295, Japan
2
Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Japan
3
Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Japan
4
Department of Public Health, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Japan
5
Fukushima Medical Center for Children and Women, Fukushima Medical University, 1 Hikarigaoka, Fukushima 960-1295, Japan
*
Author to whom correspondence should be addressed.
Membership of the Japan Environment and Children’s Study (JECS) Group is provided in the Acknowledgments.
Nutrients 2020, 12(11), 3482; https://doi.org/10.3390/nu12113482
Received: 24 October 2020 / Accepted: 11 November 2020 / Published: 13 November 2020
(This article belongs to the Special Issue Perinatal Nutrition)
We aimed to examine the impact of a daily pro-inflammatory diet during pregnancy on intrapartum fetal acidemia using a large birth cohort study in Japan. We used data on singleton pregnancies in the Japan Environment and Children’s Study (JECS) involving births from 2011 to 2014 through vaginal delivery to calculate the maternal dietary inflammatory index (DII). Participants were categorized according to DII quintiles. A multiple logistic regression model was used to estimate the risk of a pro-inflammatory diet on fetal umbilical artery pH. In total, 56,490 participants were eligible for this study. Multiple regression analysis showed that nulliparous women who had undergone vaginal delivery and were consuming a pro-inflammatory diet had an increased risk of pH < 7.10 (adjusted odds ratio [aOR]: 1.64, 95% confidence interval [CI]: 1.12–2.39). Among these women, the risk of pH < 7.10 was not affected by the duration of labor (aOR: 1.64, 95% CI: 1.11–2.42). In conclusion, following a pro-inflammatory diet during pregnancy is a risk factor for fetal acidosis among nulliparous women undergoing vaginal delivery. A high DII diet during pregnancy may modify the intrapartum fetal heart rate pattern via intrauterine inflammation. View Full-Text
Keywords: pro-inflammatory diet; pregnancy; dietary inflammatory index; fetal acidosis; umbilical artery pH pro-inflammatory diet; pregnancy; dietary inflammatory index; fetal acidosis; umbilical artery pH
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MDPI and ACS Style

Kyozuka, H.; Murata, T.; Fukuda, T.; Yamaguchi, A.; Kanno, A.; Yasuda, S.; Sato, A.; Ogata, Y.; Kuse, M.; Hosoya, M.; Yasumura, S.; Hashimoto, K.; Nishigori, H.; Fujimori, K.; the Japan Environment and Children’s Study Group. Dietary Inflammatory Index during Pregnancy and the Risk of Intrapartum Fetal Asphyxia: The Japan Environment and Children’s Study. Nutrients 2020, 12, 3482. https://doi.org/10.3390/nu12113482

AMA Style

Kyozuka H, Murata T, Fukuda T, Yamaguchi A, Kanno A, Yasuda S, Sato A, Ogata Y, Kuse M, Hosoya M, Yasumura S, Hashimoto K, Nishigori H, Fujimori K, the Japan Environment and Children’s Study Group. Dietary Inflammatory Index during Pregnancy and the Risk of Intrapartum Fetal Asphyxia: The Japan Environment and Children’s Study. Nutrients. 2020; 12(11):3482. https://doi.org/10.3390/nu12113482

Chicago/Turabian Style

Kyozuka, Hyo, Tsuyoshi Murata, Toma Fukuda, Akiko Yamaguchi, Aya Kanno, Shun Yasuda, Akiko Sato, Yuka Ogata, Masahito Kuse, Mitsuaki Hosoya, Seiji Yasumura, Koichi Hashimoto, Hidekazu Nishigori, Keiya Fujimori, and the Japan Environment and Children’s Study Group. 2020. "Dietary Inflammatory Index during Pregnancy and the Risk of Intrapartum Fetal Asphyxia: The Japan Environment and Children’s Study" Nutrients 12, no. 11: 3482. https://doi.org/10.3390/nu12113482

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