Next Article in Journal
Effect of Fat-Soluble Vitamins A, D, E and K on Vitamin Status and Metabolic Profile in Patients with Fat Malabsorption with and without Urolithiasis
Next Article in Special Issue
The Emerging Role of Vitamin C in the Prevention and Treatment of COVID-19
Previous Article in Journal
Supplementation with Red Wine Extract Increases Insulin Sensitivity and Peripheral Blood Mononuclear Sirt1 Expression in Nondiabetic Humans
Previous Article in Special Issue
Low Vitamin C Status in Patients with Cancer Is Associated with Patient and Tumor Characteristics
Review

The Effect of Perioperative Vitamin C on Postoperative Analgesic Consumption: A Meta-Analysis of Randomized Controlled Trials

1
Department of Anesthesiology, Chi Mei Medical Center, Tainan City 71004, Taiwan
2
Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan City 71710, Taiwan
3
Center of General Education, Chia Nan University of Pharmacy and Science, Tainan City 71710, Taiwan
4
Post-Baccalaureate Program in Nursing, College of Nursing, Taipei Medical University, Taipei City 11042, Taiwan
5
Cochrane Taiwan, Taipei Medical University, Taipei City 11042, Taiwan
6
Center for Nursing and Healthcare Research in Clinical Practice Application, Wan Fang Hospital, Taipei Medical University, Taipei City 11042, Taiwan
7
Evidence-Based Knowledge Translation Center, Wan Fang Hospital, Taipei Medical University, Taipei City 11042, Taiwan
8
Department of the Senior Citizen Service Management, Chia Nan University of Pharmacy and Science, Tainan City 71710, Taiwan
9
College of Health Sciences, Chang Jung Christian University, Tainan City 71101, Taiwan
10
Department of Anesthesiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung City 83301, Taiwan
11
Department of Emergency Medicine, E-Da Hospital, Kaohsiung City 82445, Taiwan
12
College of Medicine, I-Shou University, Kaohsiung City 82445, Taiwan
*
Authors to whom correspondence should be addressed.
Nutrients 2020, 12(10), 3109; https://doi.org/10.3390/nu12103109
Received: 9 September 2020 / Revised: 22 September 2020 / Accepted: 1 October 2020 / Published: 12 October 2020
(This article belongs to the Special Issue Vitamin C: From Bench to Bedside)
Because the analgesic effect of vitamin C against acute pain remains poorly addressed, this meta-analysis aimed at investigating its effectiveness against acute postoperative pain. A total of seven randomized controlled trials with placebo/normal controls were identified from PubMed, Cochrane Library, Medline, Google Scholar, and Embase databases. Pooled analysis showed a lower pain score (standardized mean difference (SMD) = −0.68, 95% CI: −1.01 to −0.36, p < 0.0001; I2 = 57%) and a lower morphine consumption (weighted mean difference (WMD) = −2.44 mg, 95% CI: −4.03 to −0.86, p = 0.003; I2 = 52%) in the vitamin group than that in the placebo group within postoperative 1–2 h. At postoperative 24 h, a lower pain score (SMD = −0.65, 95% CI: −1.11 to −0.19, p = 0.005; I2 = 81%) and lower morphine consumption (WMD = −6.74 mg, 95% CI: −9.63 to −3.84, p < 0.00001; I2 = 85%) were also noted in the vitamin group. Subgroup analyses demonstrated significant reductions in pain severity and morphine requirement immediately (1–2 h) and 24 h after surgery for patients receiving intravenous vitamin C but not in the oral subgroup. These findings showed significant reductions in pain score and opioid requirement up to postoperative 24 h, respectively, suggesting the effectiveness of perioperative vitamin C use. Further large-scale trials are warranted to elucidate its optimal intravenous dosage and effectiveness against chronic pain in the postoperative pain control setting. View Full-Text
Keywords: vitamin C; analgesic requirement; surgery; anesthesia vitamin C; analgesic requirement; surgery; anesthesia
Show Figures

Graphical abstract

MDPI and ACS Style

Hung, K.-C.; Lin, Y.-T.; Chen, K.-H.; Wang, L.-K.; Chen, J.-Y.; Chang, Y.-J.; Wu, S.-C.; Chiang, M.-H.; Sun, C.-K. The Effect of Perioperative Vitamin C on Postoperative Analgesic Consumption: A Meta-Analysis of Randomized Controlled Trials. Nutrients 2020, 12, 3109. https://doi.org/10.3390/nu12103109

AMA Style

Hung K-C, Lin Y-T, Chen K-H, Wang L-K, Chen J-Y, Chang Y-J, Wu S-C, Chiang M-H, Sun C-K. The Effect of Perioperative Vitamin C on Postoperative Analgesic Consumption: A Meta-Analysis of Randomized Controlled Trials. Nutrients. 2020; 12(10):3109. https://doi.org/10.3390/nu12103109

Chicago/Turabian Style

Hung, Kuo-Chuan, Yao-Tsung Lin, Kee-Hsin Chen, Li-Kai Wang, Jen-Yin Chen, Ying-Jen Chang, Shao-Chun Wu, Min-Hsien Chiang, and Cheuk-Kwan Sun. 2020. "The Effect of Perioperative Vitamin C on Postoperative Analgesic Consumption: A Meta-Analysis of Randomized Controlled Trials" Nutrients 12, no. 10: 3109. https://doi.org/10.3390/nu12103109

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop