Longitudinal Changes in Resting Metabolic Rates with Aging Are Accelerated by Diseases
National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
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Nutrients 2020, 12(10), 3061; https://doi.org/10.3390/nu12103061
Received: 1 September 2020
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Revised: 29 September 2020
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Accepted: 2 October 2020
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Published: 7 October 2020
(This article belongs to the Special Issue Energy Consumption and Expenditure in the Prevention of Age-Associated Diseases)
Resting metabolic rate (RMR) declines with aging and is related to changes in health status, but how specific health impairments impact basal metabolism over time has been largely unexplored. We analyzed the association of RMR with 15 common age-related chronic diseases for up to 13 years of follow-up in a population of 997 participants to the Baltimore Longitudinal Study of Aging. At each visit, participants underwent measurements of RMR by indirect calorimetry and body composition by DEXA. Linear regression models and linear mixed effect models were used to test cross-sectional and longitudinal associations of RMR and changes in disease status. Cancer and diabetes were associated with higher RMR at baseline. Independent of covariates, prevalent COPD and cancer, as well as incident diabetes, heart failure, and CKD were associated with a steeper decline in RMR over time. Chronic diseases seem to have a two-phase association with RMR. Initially, RMR may increase because of the high cost of resiliency homeostatic mechanisms. However, as the reserve capacity becomes exhausted, a catabolic cascade becomes unavoidable, resulting in loss of total and metabolically active mass and consequent RMR decline.
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Keywords:
resting metabolic rate; chronic diseases; aging; body composition
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MDPI and ACS Style
Zampino, M.; AlGhatrif, M.; Kuo, P.-L.; Simonsick, E.M.; Ferrucci, L. Longitudinal Changes in Resting Metabolic Rates with Aging Are Accelerated by Diseases. Nutrients 2020, 12, 3061. https://doi.org/10.3390/nu12103061
AMA Style
Zampino M, AlGhatrif M, Kuo P-L, Simonsick EM, Ferrucci L. Longitudinal Changes in Resting Metabolic Rates with Aging Are Accelerated by Diseases. Nutrients. 2020; 12(10):3061. https://doi.org/10.3390/nu12103061
Chicago/Turabian StyleZampino, Marta, Majd AlGhatrif, Pei-Lun Kuo, Eleanor M. Simonsick, and Luigi Ferrucci. 2020. "Longitudinal Changes in Resting Metabolic Rates with Aging Are Accelerated by Diseases" Nutrients 12, no. 10: 3061. https://doi.org/10.3390/nu12103061
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