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Microbiota and Diabetes Mellitus: Role of Lipid Mediators

Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela
Escuela de Nutrición y Dietética, Facultad de Medicina, Universidad Andres Bello, Sede Concepción 4260000, Chile
Facultad de Ciencias de la Salud, Universidad Simón Bolívar, Barranquilla 080001, Colombia
Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana 122001, India
Departamento de Endocrinología y Nutrición, Hospital General Universitario Gregorio Marañón, 28009 Madrid, Spain
Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
Author to whom correspondence should be addressed.
Nutrients 2020, 12(10), 3039;
Received: 3 July 2020 / Revised: 23 August 2020 / Accepted: 27 August 2020 / Published: 3 October 2020
(This article belongs to the Special Issue Recent Advances in Nutrition and Diabetes)
Diabetes Mellitus (DM) is an inflammatory clinical entity with different mechanisms involved in its physiopathology. Among these, the dysfunction of the gut microbiota stands out. Currently, it is understood that lipid products derived from the gut microbiota are capable of interacting with cells from the immune system and have an immunomodulatory effect. In the presence of dysbiosis, the concentration of lipopolysaccharides (LPS) increases, favoring damage to the intestinal barrier. Furthermore, a pro-inflammatory environment prevails, and a state of insulin resistance and hyperglycemia is present. Conversely, during eubiosis, the production of short-chain fatty acids (SCFA) is fundamental for the maintenance of the integrity of the intestinal barrier as well as for immunogenic tolerance and appetite/satiety perception, leading to a protective effect. Additionally, it has been demonstrated that alterations or dysregulation of the gut microbiota can be reversed by modifying the eating habits of the patients or with the administration of prebiotics, probiotics, and symbiotics. Similarly, different studies have demonstrated that drugs like Metformin are capable of modifying the composition of the gut microbiota, promoting changes in the biosynthesis of LPS, and the metabolism of SCFA. View Full-Text
Keywords: diabetes; inflammation; microbiota; dysbiosis; lipopolysaccharides; short-chain fatty acids diabetes; inflammation; microbiota; dysbiosis; lipopolysaccharides; short-chain fatty acids
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MDPI and ACS Style

Salazar, J.; Angarita, L.; Morillo, V.; Navarro, C.; Martínez, M.S.; Chacín, M.; Torres, W.; Rajotia, A.; Rojas, M.; Cano, C.; Añez, R.; Rojas, J.; Bermudez, V. Microbiota and Diabetes Mellitus: Role of Lipid Mediators. Nutrients 2020, 12, 3039.

AMA Style

Salazar J, Angarita L, Morillo V, Navarro C, Martínez MS, Chacín M, Torres W, Rajotia A, Rojas M, Cano C, Añez R, Rojas J, Bermudez V. Microbiota and Diabetes Mellitus: Role of Lipid Mediators. Nutrients. 2020; 12(10):3039.

Chicago/Turabian Style

Salazar, Juan, Lissé Angarita, Valery Morillo, Carla Navarro, María S. Martínez, Maricarmen Chacín, Wheeler Torres, Arush Rajotia, Milagros Rojas, Clímaco Cano, Roberto Añez, Joselyn Rojas, and Valmore Bermudez. 2020. "Microbiota and Diabetes Mellitus: Role of Lipid Mediators" Nutrients 12, no. 10: 3039.

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