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Open AccessArticle

Effects of Lactobacillus plantarum Q180 on Postprandial Lipid Levels and Intestinal Environment: A Double-Blind, Randomized, Placebo-Controlled, Parallel Trial

1
Department of Food Science and Technology, Seoul National University of Science and Technology, Seoul 01811, Korea
2
Department of Family Medicine, Ewha Womans University College of Medicine, Mokdong Hospital, Seoul 07985, Korea
3
Probiotics Research Laboratory, CKDBiO Research Institute, Ansan-si, Gyeonggi-do 15604, Korea
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(1), 255; https://doi.org/10.3390/nu12010255
Received: 26 December 2019 / Revised: 8 January 2020 / Accepted: 14 January 2020 / Published: 19 January 2020
(This article belongs to the Section Prebiotics and Probiotics)
Probiotics can improve the intestinal environment by enhancing beneficial bacteria to potentially regulate lipid levels; however, the underlying mechanisms remain unclear. The aim of this study was to investigate the effect of Lactobacillus plantarum Q180 (LPQ180) on postprandial lipid metabolism and the intestinal microbiome environment from a clinical perspective. A double-blind, randomized, placebo-controlled study was conducted including 70 participants of both sexes, 20 years of age and older, with healthy blood triacylglyceride (TG) levels below 200 mg/dL. Treatment with LPQ180 for 12 weeks significantly decreased LDL-cholesterol (p = 0.042) and apolipoprotein (Apo)B-100 (p = 0.003) levels, and decreased postprandial maximum concentrations (Cmax) and areas under the curve (AUC) of TG, chylomicron TG, ApoB-48, and ApoB-100. LPQ180 treatment significantly decreased total indole and phenol levels (p = 0.019). In addition, there was a negative correlation between baseline microbiota abundance and lipid marker change, which was negatively correlated with metabolites. This study suggests that LPQ180 might be developed as a functional ingredient to help maintain healthy postprandial lipid levels through modulating gut environment. View Full-Text
Keywords: postprandial lipids; intestinal microbiota; intestinal microbiota metabolites; correlation; lipid mechanism; LPQ180; probiotics postprandial lipids; intestinal microbiota; intestinal microbiota metabolites; correlation; lipid mechanism; LPQ180; probiotics
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Park, Y.E.; Kim, M.S.; Shim, K.W.; Kim, Y.-I.; Chu, J.; Kim, B.-K.; Choi, I.S.; Kim, J.Y. Effects of Lactobacillus plantarum Q180 on Postprandial Lipid Levels and Intestinal Environment: A Double-Blind, Randomized, Placebo-Controlled, Parallel Trial. Nutrients 2020, 12, 255.

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