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The Effect of Donor Human Milk Fortification on The Adhesion of Probiotics In Vitro

1
Functional Foods Forum, Faculty of Medicine, University of Turku, Itäinen Pitkäkatu 4A, 20520 Turku, Finland
2
DuPont Nutrition and Biosciences, Sokeritehtaantie 20, 02460 Kantvik, Finland
3
Unit of Biostatistics, Department of Clinical Medicine University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland
4
Department of Pediatrics, University of Turku and Turku University Hospital, Kiinamyllynkatu 4-8, 20520 Turku, Finland
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(1), 182; https://doi.org/10.3390/nu12010182
Received: 5 December 2019 / Revised: 1 January 2020 / Accepted: 4 January 2020 / Published: 9 January 2020
(This article belongs to the Section Prebiotics and Probiotics)
Preterm delivery complications are the primary cause of death among children under the age of five. Preventive strategies include the use of pasteurized donor human milk (DHM), its fortification with human milk fortifiers (protein supplements), and supplementation with probiotics. Our aim was to examine the impact of DHM and fortified DHM (FDHM) on the mucus adhesion properties of two widely used probiotics. The study covered two forms of human milk fortifier, liquid and powdered, with or without probiotics and storage at 4 °C for 24 h. To test the adhesion properties of the probiotic strains, DHM+probiotics and FDHM+probiotics were prepared and added to immobilized mucus isolated from the stool of healthy Finnish infants. The probiotic adhesion was then measured by liquid scintillation. Our results suggest that addition of liquid or powdered human milk fortifier in donor human milk had no impact on probiotic adhesion. In addition, given the increased adhesion of probiotics suspended in buffer, other matrices should be further studied. These factors need to be considered when designing future intervention strategies using probiotics in preterm infants. View Full-Text
Keywords: human milk fortifier; infant nutrition; preterm infant; Lactobacillus rhamnosus GG; Bifidobacterium animalis subsp. lactis Bb12 human milk fortifier; infant nutrition; preterm infant; Lactobacillus rhamnosus GG; Bifidobacterium animalis subsp. lactis Bb12
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Mantziari, A.; Tölkkö, S.; Ouwehand, A.C.; Löyttyniemi, E.; Isolauri, E.; Salminen, S.; Rautava, S. The Effect of Donor Human Milk Fortification on The Adhesion of Probiotics In Vitro. Nutrients 2020, 12, 182.

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