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Changes in Age at Diagnosis and Nutritional Course of Celiac Disease in the Last Two Decades

Fellow, Pediatric Gastroenterology and Nutrition Program, Faculty of Medicine, University of Chile, Santiago, Chile, Clínica Alemana de Santiago, Chile
Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile
Hospital Roberto del Río, Santiago, Chile
Hospital Exequiel González Cortés, Santiago, Chile
Hospital Luis Calvo Mackenna, Santiago, Chile
Department of Nutrition, Faculty of Medicine, University of Chile, Santiago, Chile
Author to whom correspondence should be addressed.
Nutrients 2020, 12(1), 156;
Received: 4 December 2019 / Revised: 31 December 2019 / Accepted: 2 January 2020 / Published: 6 January 2020
(This article belongs to the Section Clinical Nutrition)
The frequency of celiac disease (CD) has increased along time, with relevant changes reported in geographical variations, clinical presentation and nutritional repercussions. In recent years, some celiac patients are presenting overweight/obesity, but it is unclear how frequent this is and to what extent undernutrition remains a concern. This is relevant because CD tends to be overlooked in overweight patients. With this in mind, we assessed age at diagnosis, clinical characteristics and nutritional status of 155 celiac patients diagnosed between 1994–2017 in four pediatric hospitals in Santiago, Chile. Since 2003, the number of patients diagnosed has increased (p < 0.0033), coinciding with antitransglutaminase and antiendomysial antibodies becoming available to public health systems. In 2000, 4.5% of patients were asymptomatic at diagnosis, suggesting that active search is not routinely applied. Gastrointestinal symptoms plus failure to thrive were significantly more frequent under 2 years (p = 0.0001). Nutritional status has improved at diagnosis and during follow up, but undernutrition remains more frequent in children <2 and <5 years (p < 0.002 and p < 0.0036, respectively). Overweight at diagnosis was reported in 2002 and obesity in 2010. After initiating treatment, since 2010, patients changing from undernourishment to overweight has sometimes been observed after only 6 months on a gluten-free diet. View Full-Text
Keywords: celiac disease; age; nutritional status; follow up celiac disease; age; nutritional status; follow up
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Villanueva, M.; Oyarzún, A.; Leyton, B.; González, M.; Navarro, E.; Canales, P.; Ossa, C.; Muñoz, M.P.; Bascuñán, K.A.; Araya, M. Changes in Age at Diagnosis and Nutritional Course of Celiac Disease in the Last Two Decades. Nutrients 2020, 12, 156.

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