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Dietary Acid Load: A Novel Nutritional Target in Overweight/Obese Children with Asthma?

Faculdade de Ciências da Nutrição e Alimentação da Universidade do Porto, 4200-465 Porto, Portugal
Imunologia Básica e Clínica, Departamento de Patologia, Faculdade de Medicina, Universidade do Porto, 4200-319 Porto, Portugal
EPIUnit Instituto de Saúde Pública, Universidade do Porto, 4050-600 Porto, Portugal
Institute of Science and Innovation in Mechanical Engineering and Industrial Management (INEGI), 4200-465 Porto, Portugal
Serviço de Imunoalergologia, Centro Hospitalar Universitário de São João, 4200-319 Porto, Portugal
Author to whom correspondence should be addressed.
Nutrients 2019, 11(9), 2255;
Received: 20 August 2019 / Revised: 10 September 2019 / Accepted: 12 September 2019 / Published: 19 September 2019
Obesity has been repeatedly linked to asthma, and several potential mechanisms have been proposed in the etiologies of the obese-asthma phenotype. Considering that lungs play an important role in systemic pH and acid–base regulation, are a key organ in asthma development, and that nutritional inadequacy of several nutrients and high dietary acid load can affect airway inflammation and reactivity, we aimed to test the hypothesis that dietary acid load may be associated with asthma in children. Data on 699 children (52% females), aged 7–12 years, were analyzed. Anthropometric measurements were performed to assess body mass index. Dietary acid load was calculated using potential renal acid load (PRAL) equations from a 24 h dietary recall administrated to children. Adjusted PRAL for total energy intake was applied with the use of the residual method. Lung function and airway reversibility were assessed with spirometry. Asthma was defined by a positive bronchodilation or self-reported medical diagnosis with reported symptoms (wheezing, dyspnea, or dry cough) in the past 12 months. After adjustment for energy intake, sex, age, parent’s education level, and physical activity, positive and significant associations were found between asthma and PRAL [odds ratio (OR) = 1.953, 95% CI = 1.024, 3.730) in overweight/obese children. Our findings suggest that dietary acid load might be a possible mechanism in overweight/obese-asthma phenotype development. View Full-Text
Keywords: asthma; obesity; dietary acid load; PRAL asthma; obesity; dietary acid load; PRAL
MDPI and ACS Style

Cunha, P.; Paciência, I.; Cavaleiro Rufo, J.; Castro Mendes, F.; Farraia, M.; Barros, R.; Silva, D.; Delgado, L.; Padrão, P.; Moreira, A.; Moreira, P. Dietary Acid Load: A Novel Nutritional Target in Overweight/Obese Children with Asthma? Nutrients 2019, 11, 2255.

AMA Style

Cunha P, Paciência I, Cavaleiro Rufo J, Castro Mendes F, Farraia M, Barros R, Silva D, Delgado L, Padrão P, Moreira A, Moreira P. Dietary Acid Load: A Novel Nutritional Target in Overweight/Obese Children with Asthma? Nutrients. 2019; 11(9):2255.

Chicago/Turabian Style

Cunha, Pedro, Inês Paciência, João Cavaleiro Rufo, Francisca Castro Mendes, Mariana Farraia, Renata Barros, Diana Silva, Luís Delgado, Patrícia Padrão, André Moreira, and Pedro Moreira. 2019. "Dietary Acid Load: A Novel Nutritional Target in Overweight/Obese Children with Asthma?" Nutrients 11, no. 9: 2255.

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