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Open AccessArticle

Soluble CD14 in Breast Milk and Its Relation to Atopic Manifestations in Early Infancy

1
Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba 2608670, Japan
2
Department of Pediatrics, Japanese Red Cross Katsushika Maternity Hospital, Tokyo 1240012, Japan
3
Research and Education Center of Health Sciences, Gunma University Graduate School of Health Sciences, Gunma 3718510, Japan
4
Department of Dermatology, Graduate School of Medicine, Chiba University, Chiba 2608670, Japan
5
RIKEN Center for Integrative Medical Sciences, Yokohama City, Kanagawa 2300045, Japan
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(9), 2118; https://doi.org/10.3390/nu11092118
Received: 15 July 2019 / Revised: 29 August 2019 / Accepted: 30 August 2019 / Published: 5 September 2019
(This article belongs to the Special Issue Nutrition, Diet, and Allergic Diseases)
Soluble CD14 (sCD14) is one of the immunomodulatory factors in breast milk (BM). Although it may be involved in the prevention of atopic symptoms and sensitization to both food and inhalant allergens, conflicting evidence exists concerning its protective effects. In this study, we investigated the relationship between sCD14 in colostrum and 1-month BM, and the development of atopic dermatitis (AD) and sensitization to food and aeroallergens at 9 months of age in infants who were exclusively or almost exclusively breastfed up to 4 months of age. BM samples were collected from lactating mothers who participated in a 2 × 2 factorial, randomized, nontreatment controlled trial study set in Tokyo, which looked at the efficacy of emollients and synbiotics in preventing AD and food allergy in children during the first year of life. A total of 258 colostrum samples and 269 1-month BM samples were analyzed. We found that one-month BM sCD14 levels in the AD group were significantly lower than in the non-AD group. Levels of sCD14 in 1-month BM were not related to allergen sensitization in the overall analysis, but egg white sensitization correlated inversely with 1-month BM sCD14 in infants without AD. The results suggest that sCD14 in BM may be involved in atopic manifestations in early infancy. View Full-Text
Keywords: soluble CD14; breast milk; atopic dermatitis; allergen sensitization soluble CD14; breast milk; atopic dermatitis; allergen sensitization
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Fikri, B.; Tani, Y.; Nagai, K.; Sahara, M.; Mitsuishi, C.; Togawa, Y.; Nakano, T.; Yamaide, F.; Ohno, H.; Shimojo, N. Soluble CD14 in Breast Milk and Its Relation to Atopic Manifestations in Early Infancy. Nutrients 2019, 11, 2118.

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