Next Article in Journal
A Multi-Year Examination of Gardening Experience and Fruit and Vegetable Intake During College
Next Article in Special Issue
New and Preliminary Evidence on Altered Oral and Gut Microbiota in Individuals with Autism Spectrum Disorder (ASD): Implications for ASD Diagnosis and Subtyping Based on Microbial Biomarkers
Previous Article in Journal
The Potential for Renal Injury Elicited by Physical Work in the Heat
Previous Article in Special Issue
The Interplay between Maternal and Post-Weaning High-Fat Diet and Gut Microbiota in the Developmental Programming of Hypertension
Open AccessArticle

Effects of Regular Kefir Consumption on Gut Microbiota in Patients with Metabolic Syndrome: A Parallel-Group, Randomized, Controlled Study

1
Department of Nutrition and Dietetics, Faculty of Health Sciences, Hacettepe University, Ankara 06230, Turkey
2
Department of Nutrition and Dietetics, Faculty of Health Sciences, Izmir Katip Celebi University, Izmir 35620, Turkey
3
Department of Endocrinology, Faculty of Medicine, Ege University, Izmir 35040, Turkey
4
Department of Medical Microbiology, Faculty of Medicine, Hacettepe University, Ankara 06230, Turkey
5
Department of Biochemistry, Faculty of Pharmacy, Ege University, Izmir 35040, Turkey
6
Department of Dairy Technology, Faculty of Agriculture, Ege University, Izmir 35040, Turkey
7
Robert Koch Institute; Center for Biological Threats and Special Pathogens 1 (ZBS-1), Berlin 13353, Germany
8
Department of Medical Biology, Acıbadem Mehmet Ali Aydınlar University, Istanbul 34752, Turkey
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(9), 2089; https://doi.org/10.3390/nu11092089
Received: 13 August 2019 / Revised: 21 August 2019 / Accepted: 22 August 2019 / Published: 4 September 2019
(This article belongs to the Special Issue Nutrition, Microbiota and Noncommunicable Diseases)
Several health-promoting effects of kefir have been suggested, however, there is limited evidence for its potential effect on gut microbiota in metabolic syndrome This study aimed to investigate the effects of regular kefir consumption on gut microbiota composition, and their relation with the components of metabolic syndrome. In a parallel-group, randomized, controlled clinical trial setting, patients with metabolic syndrome were randomized to receive 180 mL/day kefir (n = 12) or unfermented milk (n = 10) for 12 weeks. Anthropometrical measurements, blood samples, blood pressure measurements, and fecal samples were taken at the beginning and end of the study. Fasting insulin, HOMA-IR, TNF-α, IFN-γ, and systolic and diastolic blood pressure showed a significant decrease by the intervention of kefir (p ≤ 0.05, for each). However, no significant difference was obtained between the kefir and unfermented milk groups (p > 0.05 for each). Gut microbiota analysis showed that regular kefir consumption resulted in a significant increase only in the relative abundance of Actinobacteria (p = 0.023). No significant change in the relative abundance of Bacteroidetes, Proteobacteria or Verrucomicrobia by kefir consumption was obtained. Furthermore, the changes in the relative abundance of sub-phylum bacterial populations did not differ significantly between the groups (p > 0.05, for each). Kefir supplementation had favorable effects on some of the metabolic syndrome parameters, however, further investigation is needed to understand its effect on gut microbiota composition. View Full-Text
Keywords: kefir; gut microbiota; metabolic syndrome kefir; gut microbiota; metabolic syndrome
Show Figures

Figure 1

MDPI and ACS Style

BELLIKCI-KOYU, E.; SARER-YUREKLI, B.P.; AKYON, Y.; AYDIN-KOSE, F.; KARAGOZLU, C.; OZGEN, A.G.; BRINKMANN, A.; NITSCHE, A.; ERGUNAY, K.; YILMAZ, E.; BUYUKTUNCER, Z. Effects of Regular Kefir Consumption on Gut Microbiota in Patients with Metabolic Syndrome: A Parallel-Group, Randomized, Controlled Study. Nutrients 2019, 11, 2089.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop