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The Metabolic Benefits of Menopausal Hormone Therapy Are Not Mediated by Improved Nutritional Habits. The OsteoLaus Cohort

1
Service of Endocrinology, Diabetes and Metabolism, Lausanne University Hospital and University of Lausanne, CH-1011 Lausanne, Switzerland
2
Center of Bone Diseases, CHUV, Lausanne University Hospital and University of Lausanne, CH-1011 Lausanne, Switzerland
3
Service of Internal Medicine, CHUV, Lausanne University Hospital and University of Lausanne, CH-1011 Lausanne, Switzerland
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(8), 1930; https://doi.org/10.3390/nu11081930 (registering DOI)
Received: 8 July 2019 / Accepted: 14 August 2019 / Published: 16 August 2019
(This article belongs to the Special Issue Diet, Estrogen Metabolism and Women's Health)
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Abstract

Menopause alters body composition by increasing fat mass. Menopausal hormone therapy (MHT) is associated with decreased total and visceral adiposity. It is unclear whether MHT favorably affects energy intake. We aimed to assess in the OsteoLaus cohort whether total energy intake (TEI) and/or diet quality (macro- and micronutrients, dietary patterns, dietary scores, dietary recommendations)—evaluated by a validated food frequency questionnaire—differ in 839 postmenopausal women classified as current, past or never MHT users. There was no difference between groups regarding TEI or consumption of macronutrients. After multivariable adjustment, MHT users were less likely to adhere to the unhealthy pattern ‘fat and sugar: Current vs. never users [OR (95% CI): 0.48 (0.28–0.82)]; past vs. never users [OR (95% CI): 0.47 (0.27–0.78)]. Past users exhibited a better performance in the revised score for Mediterranean diet than never users (5.00 ± 0.12 vs. 4.63 ± 0.08, p < 0.04). Differences regarding compliance with dietary recommendations were no longer significant after adjustment for covariates. Overall, these results argue against a major role of TEI and diet quality as possible mediators of the MHT metabolic benefits. Future research on this relationship should focus on other potential targets of MHT, such as resting energy expenditure and physical activity. View Full-Text
Keywords: menopause; estrogens; estrogen deficiency; visceral fat; menopausal hormone therapy; energy intake; macronutrients; dietary patterns; dietary recommendations menopause; estrogens; estrogen deficiency; visceral fat; menopausal hormone therapy; energy intake; macronutrients; dietary patterns; dietary recommendations
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Papadakis, G.E.; Hans, D.; Gonzalez Rodriguez, E.; Vollenweider, P.; Waeber, G.; Marques-Vidal, P.; Lamy, O. The Metabolic Benefits of Menopausal Hormone Therapy Are Not Mediated by Improved Nutritional Habits. The OsteoLaus Cohort. Nutrients 2019, 11, 1930.

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