Next Article in Journal
Changes in Ileal Microbial Composition and Microbial Metabolism by an Early-Life Galacto-Oligosaccharides Intervention in a Neonatal Porcine Model
Next Article in Special Issue
Energy Expenditure, Carbohydrate Oxidation and Appetitive Responses to Sucrose or Sucralose in Humans: A Pilot Study
Previous Article in Journal
Stability, Continuity, and Bi-Directional Associations of Parental Feeding Practices and Standardized Child Body Mass Index in Children from 2 to 12 Years of Age
Previous Article in Special Issue
Sugar-Sweetened Beverages Contribute Significantly to College Students’ Daily Caloric Intake in Jordan: Soft Drinks Are Not the Major Contributor
Article Menu

Export Article

Open AccessArticle

Body Mass Index Z-Score Modifies the Association between Added Sugar Intake and Arterial Stiffness in Youth with Type 1 Diabetes: The Search Nutrition Ancillary Study

1
Department of Health Sciences, Furman University, Greenville, SC 29613, USA
2
Department of Rehabilitation, Exercise and Nutrition Sciences, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA
3
The Heart Institute, Cincinnati Children’s Hospital Medical Center and Department of Pediatrics, University of Cincinnati, Cincinnati, OH 45229, USA
4
Department of Biostatistics, Gillings School of Global Public Health, School of Nursing, University of North Carolina, Chapel Hill, NC 27599, USA
5
Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA
6
Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, CO 80045, USA
7
Department of Pediatrics, University of Washington, Seattle, WA 98195, USA
8
Department of Biostatistics and Data Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA
9
Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, CA 91101, USA
10
Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(8), 1752; https://doi.org/10.3390/nu11081752
Received: 18 June 2019 / Revised: 22 July 2019 / Accepted: 25 July 2019 / Published: 30 July 2019
  |  
PDF [471 KB, uploaded 30 July 2019]
  |     |  

Abstract

The relationship between added sugar and arterial stiffness in youth with type 1 diabetes (T1D) has not been well-described. We used data from the SEARCH for Diabetes in Youth Study (SEARCH), an ongoing observational cohort study, to determine the association between added sugar and arterial stiffness in individuals diagnosed with T1D <20 years of age (n = 1539; mean diabetes duration of 7.9 ± 1.9 years). Added sugar intake was assessed by a food frequency questionnaire, and arterial stiffness measures included pulse wave velocity (PWV) and augmentation index. Separate multivariate linear regression models were used to evaluate the association between added sugar and arterial stiffness. Separate interaction terms were included to test for effect modification by body mass index (BMI) z-score and physical activity (PA). Overall, there was no association between added sugar and arterial stiffness (P > 0.05); however, the association between added sugar and arterial stiffness differed by BMI z-score (P for interaction = 0.003). For participants with lower BMI z-scores, added sugar intake was positively associated with PWV trunk measurements, whereas there was no association for those who had a higher BMI z-score. PA did not significantly modify the association between added sugar and arterial stiffness. Further research is needed to determine the longitudinal relationship and to confirm that obesity differentially affects this association. View Full-Text
Keywords: added sugar; arterial stiffness; diabetes; epidemiology; adolescents and young adults added sugar; arterial stiffness; diabetes; epidemiology; adolescents and young adults
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

The, N.S.; Couch, S.C.; Urbina, E.M.; Crandell, J.L.; Liese, A.D.; Dabelea, D.; Kim, G.J.; Tooze, J.A.; Lawrence, J.M.; Mayer-Davis, E.J. Body Mass Index Z-Score Modifies the Association between Added Sugar Intake and Arterial Stiffness in Youth with Type 1 Diabetes: The Search Nutrition Ancillary Study. Nutrients 2019, 11, 1752.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top