The Role of Muscle Mass Gain Following Protein Supplementation Plus Exercise Therapy in Older Adults with Sarcopenia and Frailty Risks: A Systematic Review and Meta-Regression Analysis of Randomized Trials

Liao, Chun-De; Chen, Hung-Chou; Huang, Shih-Wei; Liou, Tsan-Hon

doi:10.3390/nu11081713

Submit to this Journal Review for this Journal Edit a Special Issue

Article Menu

...

Comment published on 9 October 2019, see Nutrients 2019, 11(10), 2406.

Open AccessReview

The Role of Muscle Mass Gain Following Protein Supplementation Plus Exercise Therapy in Older Adults with Sarcopenia and Frailty Risks: A Systematic Review and Meta-Regression Analysis of Randomized Trials

Chun-De Liao

^1,2

Hung-Chou Chen

^2,3

Shih-Wei Huang

^2,4,5,†

and

Tsan-Hon Liou

^2,5,*,†

School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei 10055, Taiwan

Department of Physical Medicine and Rehabilitation, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan

Center for Evidence-Based Health Care, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan

⁴

Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 33301, Taiwan

⁵

Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan

Author to whom correspondence should be addressed.

^†

Shih-Wei Huang and Tsan-Hon Liou equally contributed to this study.

Nutrients 2019, 11(8), 1713; https://doi.org/10.3390/nu11081713

Received: 14 June 2019 / Revised: 22 July 2019 / Accepted: 23 July 2019 / Published: 25 July 2019

(This article belongs to the Special Issue Sarcopenia and Nutritional Status)

View Full-Text Download PDF

Browse Figures

Review Reports Citation Export

Abstract

Aging and frailty are associated with a high risk of lean mass (LM) loss, which leads to physical disability and can be effectively alleviated by protein supplementation (PS) and muscle strengthening exercise (MSE). In this study, the associations between LM gain and PS + MSE efficacy (measured using physical outcomes) in elderly patients with a high risk of sarcopenia or frailty were identified. A comprehensive search of online databases was performed to identify randomized controlled trials (RCTs) reporting the efficacy of PS + MSE in elderly patients with sarcopenia or frailty. The included RCTs were analyzed using meta-analysis and risk of bias assessment. We finally included 19 RCTs in this meta-analysis with a median (range/total) Physiotherapy Evidence Database score of 7/10 (5–9/10). The PS + MSE group exhibited significant improvements in the whole-body LM (standard mean difference (SMD) = 0.66; p < 0.00001), appendicular LM (SMD = 0.35; p < 0.00001), leg strength (SMD = 0.65; p < 0.00001), and walking capability (SMD = 0.33; p = 0.0006). Meta-regression analyses showed that changes in appendicular LM were significantly associated with the effect sizes of leg strength (β = 0.08; p = 0.003) and walking capability (β = 0.17; p = 0.04), respectively. Our findings suggest that LM gain after PS + MSE significantly contributes to the efficacy of the intervention in terms of muscle strength and physical mobility in elderly patients with a high risk of sarcopenia or frailty. View Full-Text

Keywords: sarcopenia; protein supplement; exercise training; lean body mass; physical function

▼ Show Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary File 1:
PDF-Document (PDF, 1322 KiB)

Share and Cite

MDPI and ACS Style

Liao, C.-D.; Chen, H.-C.; Huang, S.-W.; Liou, T.-H. The Role of Muscle Mass Gain Following Protein Supplementation Plus Exercise Therapy in Older Adults with Sarcopenia and Frailty Risks: A Systematic Review and Meta-Regression Analysis of Randomized Trials. Nutrients 2019, 11, 1713. https://doi.org/10.3390/nu11081713

AMA Style

Liao C-D, Chen H-C, Huang S-W, Liou T-H. The Role of Muscle Mass Gain Following Protein Supplementation Plus Exercise Therapy in Older Adults with Sarcopenia and Frailty Risks: A Systematic Review and Meta-Regression Analysis of Randomized Trials. Nutrients. 2019; 11(8):1713. https://doi.org/10.3390/nu11081713

Chicago/Turabian Style

Liao, Chun-De, Hung-Chou Chen, Shih-Wei Huang, and Tsan-Hon Liou. 2019. "The Role of Muscle Mass Gain Following Protein Supplementation Plus Exercise Therapy in Older Adults with Sarcopenia and Frailty Risks: A Systematic Review and Meta-Regression Analysis of Randomized Trials" Nutrients 11, no. 8: 1713. https://doi.org/10.3390/nu11081713

Find Other Styles

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Abstract views Pdf views Html views

Article Menu

The Role of Muscle Mass Gain Following Protein Supplementation Plus Exercise Therapy in Older Adults with Sarcopenia and Frailty Risks: A Systematic Review and Meta-Regression Analysis of Randomized Trials

Abstract

Supplementary Material

Share and Cite

Article Metrics

Article Access Statistics

Article Access Map by Country/Region

Further Information

Guidelines

MDPI Initiatives

Follow MDPI