Next Article in Journal
Validation of Surrogate Anthropometric Indices in Older Adults: What Is the Best Indicator of High Cardiometabolic Risk Factor Clustering?
Previous Article in Journal
Postprandial Effects of a Proprietary Milk Protein Hydrolysate Containing Bioactive Peptides in Prediabetic Subjects
Open AccessArticle

n-3 Polyunsaturated Fatty Acids Decrease Long-Term Diabetic Risk of Offspring of Gestational Diabetes Rats by Postponing Shortening of Hepatic Telomeres and Modulating Liver Metabolism

1
Department of Food Science and Nutrition, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China
2
Hangzhou Institute for Food and Drug Control, 198 Yonghua Street, Hangzhou 310022, China
3
Institute of Nutrition and Health, Qingdao University, 308 Ningxia Road, Qingdao 266071, China
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(7), 1699; https://doi.org/10.3390/nu11071699
Received: 17 May 2019 / Revised: 16 July 2019 / Accepted: 19 July 2019 / Published: 23 July 2019
The long-term influence of gestational diabetes mellitus (GDM) on offspring and the effect of omega-3 polyunsaturated fatty acids (n-3 PUFA) on GDM offspring are poorly understood. We studied the long-term diabetic risk in GDM offspring and evaluated the effect of n-3 PUFA intervention. Healthy offspring rats were fed standard diet (soybean oil) after weaning. GDM offspring were divided into three groups: GDM offspring (soybean oil), n-3 PUFA adequate offspring (fish oil), and n-3 PUFA deficient offspring (safflower oil), fed up to 11 months old. The diabetic risk of GDM offspring gradually increased from no change at weaning to obvious impaired glucose and insulin tolerance at 11 months old. n-3 PUFA decreased oxidative stress and inflammation in the liver of older GDM offspring. There was a differential effect of n-3 PUFA and n-6 PUFA on hepatic telomere length in GDM offspring. Non-targeted metabolomics showed that n-3 PUFA played a modulating role in the liver, in which numerous metabolites and metabolic pathways were altered when GDM offspring grew to old age. Many metabolites were related to diabetes risk, such as α-linolenic acid, palmitic acid, ceramide, oxaloacetic acid, tocotrienol, tetrahydro-11-deoxycortisol, andniacinamide. In summary, GDM offspring exhibited obvious diabetes risk at old age, whereas n-3 PUFA decreased this risk. View Full-Text
Keywords: gestational diabetes mellitus; offspring; long-term effect; n-3 polyunsaturated fatty acid; diabetes risk; liver; oxidative stress; inflammation; telomere length; metabolomics gestational diabetes mellitus; offspring; long-term effect; n-3 polyunsaturated fatty acid; diabetes risk; liver; oxidative stress; inflammation; telomere length; metabolomics
Show Figures

Graphical abstract

MDPI and ACS Style

Gao, J.; Xiao, H.; Li, J.; Guo, X.; Cai, W.; Li, D. n-3 Polyunsaturated Fatty Acids Decrease Long-Term Diabetic Risk of Offspring of Gestational Diabetes Rats by Postponing Shortening of Hepatic Telomeres and Modulating Liver Metabolism. Nutrients 2019, 11, 1699.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop