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Open AccessArticle

Interaction of Dietary Linoleic Acid and α-Linolenic Acids with rs174547 in FADS1 Gene on Metabolic Syndrome Components among Vegetarians

1
Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Malaysia
2
Research Centre of Excellence, Nutrition and Non-Communicable Diseases Universiti Putra Malaysia, Serdang 43400, Malaysia
3
Programme of Sports Science, Faculty of Sports Science and Recreation, Universiti Teknologi MARA, Shah Alam 40450, Malaysia
4
Malaysia Research Institute on Ageing (MyAgeing), Universiti Putra Malaysia, Serdang 43400, Malaysia
5
Integrative Pharmacogenomics Institute (iPROMISE), Universiti Teknologi MARA, Puncak Alam 42300, Malaysia
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(7), 1686; https://doi.org/10.3390/nu11071686
Received: 30 May 2019 / Revised: 3 July 2019 / Accepted: 9 July 2019 / Published: 23 July 2019
(This article belongs to the Special Issue Selected Papers from APNNO Biennial Conference 2018)
Fatty acid desaturase 1 (FADS1) gene controls the fatty acid metabolism pathway in the human body. The lower intake of α-linolenic acid (ALA) than linoleic acid (LA) among vegetarians may disrupt the fatty acid metabolism and limit the conversion of ALA to anti-inflammatory products such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). This cross-sectional study aimed to determine the interaction of rs174547 in FADS1 gene with LA and ALA on metabolic syndrome (MetS) components. A total of 200 Chinese and Indian vegetarians in Kuala Lumpur and Selangor, Malaysia participated in the present study. The data on socio-demographic characteristics, vegetarianism practices, dietary practices, anthropometric measurements, blood pressure (BP), and overnight venous fasting blood samples were collected from the vegetarians. The rs174547 in FADS1 gene was significantly associated with MetS and its components such as waist circumference (WC) and fasting blood glucose (FBG). Multiple logistic regression analyses revealed that vegetarians with TT genotype of rs174547 in FADS1 gene had higher odds for MetS, larger WC, higher BP, and a lower level of HDL-c. Two-way ANOVA analysis showed that LA interacts with rs174547 in FADS1 gene to affect HDL-c (p < 0.05) among vegetarians. The present findings suggest the need to develop dietary guidelines for vegetarians in Malaysia. Prospective studies are also needed to affirm the interaction between LA and rs174547 in FADS1 gene on HDL-c among Malaysian vegetarians. View Full-Text
Keywords: fatty acid desaturase 1 gene; single nucleotide polymorphism; vegetarians; metabolic syndromes; linoleic acid; α-linolenic acid fatty acid desaturase 1 gene; single nucleotide polymorphism; vegetarians; metabolic syndromes; linoleic acid; α-linolenic acid
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Ching, Y.K.; Chin, Y.S.; Appukutty, M.; Ramanchadran, V.; Yu, C.Y.; Ang, G.Y.; Gan, W.Y.; Chan, Y.M.; Teh, L.K.; Salleh, M.Z. Interaction of Dietary Linoleic Acid and α-Linolenic Acids with rs174547 in FADS1 Gene on Metabolic Syndrome Components among Vegetarians. Nutrients 2019, 11, 1686.

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