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Effects of a Cod Protein Hydrolysate Supplement on Symptoms, Gut Integrity Markers and Fecal Fermentation in Patients with Irritable Bowel Syndrome

1
Centre for Nutrition, Department of Clinical Medicine, University of Bergen, 5009 Bergen, Norway
2
Division of Gastroenterology, Department of Medicine, Haukeland University Hospital, 5021 Bergen, Norway
3
National Centre of Functional Gastrointestinal Disorders, Haukeland University Hospital, 5021 Bergen, Norway
4
Unger-Vetlesen Institute, Lovisenberg Diaconal Hospital, 0440 Oslo, Norway
5
Department of Gastroenterology, Oslo University Hospital, 0450 Oslo, Norway
6
Division of Gastroenterology, Department of Medicine, Ålesund Hospital, Møre & Romsdal Hospital Trust, 6017 Ålesund, Norway
7
Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, 7491 Trondheim, Norway
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(7), 1635; https://doi.org/10.3390/nu11071635
Received: 26 June 2019 / Revised: 10 July 2019 / Accepted: 15 July 2019 / Published: 17 July 2019
(This article belongs to the Special Issue Nutritional Management of Gastrointestinal Diseases and Disorders)
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Abstract

Peptides from fish may beneficially affect several metabolic outcomes, including gut health and inflammation. The effect of fish peptides in subjects with irritable bowel syndrome (IBS) has not previously been investigated, hence this study aimed to evaluate the effect of a cod protein hydrolysate (CPH) supplement on symptom severity, gut integrity markers and fecal fermentation in IBS-patients. A double-blind, randomized parallel-intervention with six weeks of supplementation with 2.5 g CPH (n = 13) or placebo (n = 15) was conducted. The outcomes were evaluated at baseline and the end of the study. The primary outcomes were symptom severity evaluated by the IBS severity scoring system (IBS-SSS) and quality of life. The secondary outcomes included gut integrity markers and pro-inflammatory cytokines in serum, fecal fermentation measured by concentration of short-chain fatty acids (SCFAs) and fecal calprotectin. The groups were comparable at baseline. The total IBS-SSS-scores were reduced in both the CPH-group (298 ± 69 to 236 ± 106, p = 0.081) and the placebo-group (295 ± 107 to 202 ± 103, p = 0.005), but the end of study-scores did not differ (p = 0.395). The concentrations of serum markers and SCFAs did not change for any of the groups. The baseline measures for the whole group showed that the total SCFA concentrations were inversely correlated with the total IBS-SSS-score (r = −0.527, p = 0.004). Our study showed that a low dose of CPH taken daily by IBS-patients for six weeks did not affect symptom severity, gut integrity markers or fecal fermentation when compared to the placebo group. View Full-Text
Keywords: irritable bowel syndrome; bioactive fish peptide; short-chain fatty acids; low-grade inflammation; gut integrity markers irritable bowel syndrome; bioactive fish peptide; short-chain fatty acids; low-grade inflammation; gut integrity markers
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Dale, H.F.; Jensen, C.; Hausken, T.; Hatlebakk, J.G.; Brønstad, I.; Valeur, J.; Hoff, D.A.L.; Lied, G.A. Effects of a Cod Protein Hydrolysate Supplement on Symptoms, Gut Integrity Markers and Fecal Fermentation in Patients with Irritable Bowel Syndrome. Nutrients 2019, 11, 1635.

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