Next Article in Journal
Is the Canadian Healthy Eating Index 2007 an Appropriate Diet Indicator of Metabolic Health? Insights from Dietary Pattern Analysis in the PREDISE Study
Previous Article in Journal
Which Choice of Delivery Model(s) Works Best to Deliver Fortified Foods?
Previous Article in Special Issue
Impact of the Ketogenic Diet on Linear Growth in Children: A Single-Center Retrospective Analysis of 34 Cases
Article Menu

Export Article

Open AccessArticle

A Prospective Study on Changes in Nutritional Status and Growth Following Two Years of Ketogenic Diet (KD) Therapy in Children with Refractory Epilepsy

1
Department of Clinical Nutrition, Hospital de Pediatría J.P. Garrahan, C1245AAM Buenos Aires, Argentina
2
Department of Growth & Development, Hospital de Pediatría J.P. Garrahan, C1245AAM Buenos Aires, Argentina
3
Food Services Area, Hospital de Pediatría J.P. Garrahan, C1245AAM Buenos Aires, Argentina
4
Department of Neurology, Hospital de Pediatría J.P. Garrahan, C1245AAM Buenos Aires, Argentina
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(7), 1596; https://doi.org/10.3390/nu11071596
Received: 1 June 2019 / Revised: 5 July 2019 / Accepted: 8 July 2019 / Published: 14 July 2019
(This article belongs to the Special Issue Ketogenic Dietary Therapies: Recent Findings and Future Perspectives)
  |  
PDF [713 KB, uploaded 14 July 2019]
  |  

Abstract

Introduction: Epilepsy is a neurological disorder characterized by an increased susceptibility to seizures. The ketogenic diet (KD) is currently the most important alternative non-pharmacological treatment. Despite its long history of clinical use, it is not clear how this diet affects longitudinal growth in children. Methods: A prospective study was designed to evaluate growth and nutritional status in 45 children on KD. Growth was assessed by measuring weight, height, and body mass index (BMI). Standard deviation scores (SDS) were calculated for all measurement parameters at KD initiation and at a two-year follow-up. Results: Overall, 45 patients who completed 24 months on KD were enrolled. Median age was 6.6 years (0.8 to 17.3), with a male predominance (n = 23); 74% of the 45 patients were responders on seizure reduction at three months; 26% of patients were non-responders. In our study, using −1 SDS as a cut-off point, growth deceleration was observed in 9% (n: 4) of the patients; however, the nutritional status was maintained or even improved. No correlation with age, sex, or ambulatory status was found. Conclusions: The nutritional follow-up of these patients was helpful to improve overweight and thinness but could not avoid growth deceleration in some of them. These findings confirm that children with refractory epilepsy on KD treatment require careful growth monitoring. View Full-Text
Keywords: ketogenic diet; refractory epilepsy; growth; nutritional status; children ketogenic diet; refractory epilepsy; growth; nutritional status; children
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Armeno, M.; Verini, A.; del Pino, M.; Araujo, M.B.; Mestre, G.; Reyes, G.; Caraballo, R.H. A Prospective Study on Changes in Nutritional Status and Growth Following Two Years of Ketogenic Diet (KD) Therapy in Children with Refractory Epilepsy. Nutrients 2019, 11, 1596.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top