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Role of Hypovitaminosis D in the Pathogenesis of Obesity-Induced Insulin Resistance

1
Department of Experimental Medicine, Section of Physiopathology, Endocrinology and Food Science, University of Rome Sapienza, 00161 Rome, Italy
2
Department of Movement, Human and Health Sciences, Section of Health Science, University of Rome Foro Italico, 00135 Rome, Italy
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(7), 1506; https://doi.org/10.3390/nu11071506
Received: 9 June 2019 / Revised: 26 June 2019 / Accepted: 27 June 2019 / Published: 1 July 2019
(This article belongs to the Special Issue Vitamin D and Obesity)
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PDF [228 KB, uploaded 1 July 2019]
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Abstract

Obesity and type 2 diabetes have both rapidly increased during the last decades and are continuing to increase at an alarming rate worldwide. Obesity and impaired glucose homeostasis are closely related, and during the last decades of investigation about vitamin D, several clinical and epidemiological studies documented an inverse correlation between circulating vitamin D levels, central adiposity and the development of insulin resistance and diabetes. The insufficient sun exposure and outdoor activities of obese individuals, the storage of vitamin D in adipose tissue, because of its lipophilic properties, and the vitamin D-mediated modulation of adipogenesis, insulin secretion, insulin sensitivity and the immune system, are the main reasons for the close relationship between obesity, glucose homeostasis and hypovitaminosis D. Then objective of this review is to explore the pathophysiological mechanism(s) by which vitamin D modulates glycemic control and insulin sensitivity in obese individuals. View Full-Text
Keywords: obesity; insulin resistance; type 2 diabetes; vitamin D; hypovitaminosis D; inflammation obesity; insulin resistance; type 2 diabetes; vitamin D; hypovitaminosis D; inflammation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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MDPI and ACS Style

Greco, E.A.; Lenzi, A.; Migliaccio, S. Role of Hypovitaminosis D in the Pathogenesis of Obesity-Induced Insulin Resistance. Nutrients 2019, 11, 1506.

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