Next Article in Journal
Vitamin D and Obesity: Two Interacting Players in the Field of Infertility
Previous Article in Journal
Association between Dietary Calcium Intake and Adiposity in Male Adolescents
Open AccessArticle

Comparison of the Clinical Implications among Five Different Nutritional Indices in Patients with Lupus Nephritis

1
Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul 03722, Korea
2
Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul 03722, Korea
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(7), 1456; https://doi.org/10.3390/nu11071456
Received: 29 May 2019 / Revised: 17 June 2019 / Accepted: 25 June 2019 / Published: 27 June 2019
Systemic lupus erythematosus (SLE) is characterized with aberrant responses in the immune systems and lupus nephritis (LN) is one of the most serious complications of SLE. This study evaluated the clinical significance of different nutritional indices in 207 renal biopsy-proven LN patients. The clinical and laboratory data were reviewed, and five different nutritional indices were calculated: (i) Controlling nutritional status (CONUT) score; (ii) prognostic nutritional index (PNI); (iii) nutritional risk index; (iv) neutrophil-to-lymphocyte ratio; and (v) body mass index. The factors associated with end-stage renal failure (ESRF) were assessed using a Cox-proportional hazard analysis. The patients with ESRF had significantly lower median PNI (31.1 vs. 34.7, p = 0.012) than those without ESRF at baseline. The CONUT score and PNI had the highest correlation between the SLE disease activity index-2000 (r = 0.467 and p = −0.356, all p < 0.001) and was significantly associated with SLE activity-related measures. In the Cox-proportional hazard analysis, PNI (odds ratio 0.925, 95% confidence interval 0.865–0.989, p = 0.022) was independently associated with ESRF along with creatinine and chronicity index, and the renal survival rate was significantly lower in patients with PNI ≤35.41 than in those with PNI >35.41 (p = 0.003). Among nutritional indices, the CONUT score and PNI better correlated with disease activity and PNI was associated with ESRF. View Full-Text
Keywords: lupus nephritis; end-stage renal failure; nutrition; index; prognosis lupus nephritis; end-stage renal failure; nutrition; index; prognosis
Show Figures

Figure 1

MDPI and ACS Style

Ahn, S.S.; Yoo, J.; Jung, S.M.; Song, J.J.; Park, Y.-B.; Lee, S.-W. Comparison of the Clinical Implications among Five Different Nutritional Indices in Patients with Lupus Nephritis. Nutrients 2019, 11, 1456.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop