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Atherogenic Index Reduction and Weight Loss in Metabolic Syndrome Patients Treated with A Novel Pectin-Enriched Formulation of Bergamot Polyphenols

1
Villa dei Gerani Hospital, 89900 Vibo Valencia, Italy
2
Department of Health Sciences, Magna Graecia University, Campus Germaneto, 88100 Catanzaro, Italy
3
Interregional Research Center for Food Safety and Health, 88100 Catanzaro, Italy
4
Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, 10-748 Olsztyn, Poland
5
San Raffaele, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Pisana, 00163 Rome, Italy
*
Authors to whom correspondence should be addressed.
Nutrients 2019, 11(6), 1271; https://doi.org/10.3390/nu11061271
Received: 5 May 2019 / Revised: 31 May 2019 / Accepted: 3 June 2019 / Published: 4 June 2019
(This article belongs to the Special Issue Nutrition Status and Atherosclerosis)
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Abstract

Bergamot flavonoids counteract dyslipidemia and hyperglycemia but fail to induce a significant weight loss. Here, we evaluated the efficacy of bergamot polyphenol extract complex (BPE-C), a novel bergamot juice-derived formulation enriched with flavonoids and pectins, on several metabolic syndrome parameters. Obese patients with atherogenic index of plasma (AIP) over 0.34 and mild hyperglycemia were recruited to a double-blind randomized trial comparing two doses of BPE-C (650 and 1300 mg daily) with placebo. Fifty-two subjects met the inclusion criteria and were assigned to three experimental groups. Fifteen subjects per group completed 90 days-trial. BPE-C reduced significantly fasting glucose by 18.1%, triglycerides by 32% and cholesterol parameters by up to 41.4%, leading to a powerful reduction of AIP (below 0.2) in the high dose group. The homeostasis model assessment of insulin resistance (HOMA-IR) and insulin levels were also reduced. Moreover, BPE-C decreased body weight by 14.8% and body mass index by 15.9% in BPE-C high group. This correlated with a significant reduction of circulating hormones balancing caloric intake, including leptin, ghrelin and upregulation of adiponectin. All effects showed a dose-dependent tendency. This study suggests that food supplements, containing full spectrum of bergamot juice components, such as BPE-C efficiently induce a combination of weight loss and insulin sensitivity effects together with a robust reduction of atherosclerosis risk. View Full-Text
Keywords: atherosclerosis; metabolic syndrome; insulin resistance; bergamot polyphenol fraction (BPF); body mass index; clinical trial; cardiovascular risk factors; obesity atherosclerosis; metabolic syndrome; insulin resistance; bergamot polyphenol fraction (BPF); body mass index; clinical trial; cardiovascular risk factors; obesity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Capomolla, A.S.; Janda, E.; Paone, S.; Parafati, M.; Sawicki, T.; Mollace, R.; Ragusa, S.; Mollace, V. Atherogenic Index Reduction and Weight Loss in Metabolic Syndrome Patients Treated with A Novel Pectin-Enriched Formulation of Bergamot Polyphenols. Nutrients 2019, 11, 1271.

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