Next Article in Journal
Resveratrol Regulates BDNF, trkB, PSA-NCAM, and Arc Expression in the Rat Cerebral Cortex after Bilateral Common Carotid Artery Occlusion and Reperfusion
Previous Article in Journal
Effect of Adherence to Mediterranean Diet during Pregnancy on Children’s Health: A Systematic Review
Review

Circulating Saturated Fatty Acids and Incident Type 2 Diabetes: A Systematic Review and Meta-Analysis

1
Department of Medical Statistics and Epidemiology, Guangzhou Key Laboratory of Environmental Pollution and Health Assessment, Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China
2
Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA
3
Department of Obstetrics and Gynecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119074, Singapore
4
Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore 117609, Singapore
5
Department of Information Management, Xinhua College, Sun Yat-sen University, Guangzhou 510520, China
6
Division of Obstetrics and Gynecology, KK Women’s and Children’s Hospital, Singapore 229899, Singapore
7
Obstetrics and Gynecology Academic Clinical Program, Duke-NUS Medical School, Singapore 169857, Singapore
8
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 169856, Singapore
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(5), 998; https://doi.org/10.3390/nu11050998
Received: 12 April 2019 / Revised: 28 April 2019 / Accepted: 30 April 2019 / Published: 1 May 2019
The effect of saturated fatty acids (SFAs) on incident type 2 diabetes (T2D) is controversial and few have systematically appraised the evidence. We conducted a comprehensive search of prospective studies examining these relationships that were published in PubMed, Web of Science, or EMBASE from 21 February 1989 to 21 February 2019. A total of 19 studies were included for systematic review and 10 for meta-analysis. We estimated the summarized relative risk (RR) and 95% confidence interval (95% CI) using a random (if I2 > 50%) or a fixed effects model (if I2 ≤ 50%). Although the included studies reported inconclusive results, the majority supported a protective effect of odd-chain and an adverse impact of even-chain SFAs. Meta-analysis showed that the per standard deviation (SD) increase in odd-chain SFAs was associated with a reduced risk of incident T2D (C15:0: 0.86, 0.76–0.98; C17:0: 0.76, 0.59–0.97), while a per SD increase in one even-chain SFA was associated with an increased risk of incident T2D (C14:0: 1.13, 1.09–1.18). No associations were found between other SFAs and incident T2D. In conclusion, our findings suggest an overall protective effect of odd-chain SFAs and the inconclusive impact of even- and very-long-chain SFAs on incident T2D. View Full-Text
Keywords: type 2 diabetes; incidence; prospective cohort study; saturated fatty acids; circulating; meta-analysis; systematic review type 2 diabetes; incidence; prospective cohort study; saturated fatty acids; circulating; meta-analysis; systematic review
Show Figures

Figure 1

MDPI and ACS Style

Huang, L.; Lin, J.-s.; Aris, I.M.; Yang, G.; Chen, W.-Q.; Li, L.-J. Circulating Saturated Fatty Acids and Incident Type 2 Diabetes: A Systematic Review and Meta-Analysis. Nutrients 2019, 11, 998. https://doi.org/10.3390/nu11050998

AMA Style

Huang L, Lin J-s, Aris IM, Yang G, Chen W-Q, Li L-J. Circulating Saturated Fatty Acids and Incident Type 2 Diabetes: A Systematic Review and Meta-Analysis. Nutrients. 2019; 11(5):998. https://doi.org/10.3390/nu11050998

Chicago/Turabian Style

Huang, Lihua, Jie-sheng Lin, Izzuddin M. Aris, Guiyou Yang, Wei-Qing Chen, and Ling-Jun Li. 2019. "Circulating Saturated Fatty Acids and Incident Type 2 Diabetes: A Systematic Review and Meta-Analysis" Nutrients 11, no. 5: 998. https://doi.org/10.3390/nu11050998

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop