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Isocaloric Substitution of Dietary Carbohydrate Intake with Fat Intake and MRI-Determined Total Volumes of Visceral, Subcutaneous and Hepatic Fat Content in Middle-Aged Adults

1
Chair of Epidemiology, Ludwig-Maximilians Universität München at UNIKA-T Augsburg, 86156 Augsburg, Germany
2
Independent Research Group Clinical Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany
3
Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany
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Siegfried Weller Institute for Trauma Research, BG Trauma Center Tuebingen, Eberhard-Karls University Tuebingen, 72074 Tuebingen, Germany
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Department of Radiology, Ludwig Maximilians University Hospital, 81377 Munich, Germany
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German Center for Diabetes Research (DZD), 85764 München-Neuherberg, Germany
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Department of Diagnostic and Interventional Radiology, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(5), 1151; https://doi.org/10.3390/nu11051151
Received: 2 May 2019 / Revised: 17 May 2019 / Accepted: 20 May 2019 / Published: 23 May 2019
The present study investigated the association of carbohydrate intake and isocaloric substitution with different types of fat with visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT) and hepatic fat content as determined by magnetic resonance imaging (MRI). Data from 283 participants (mean age 56.1 ± 9.0 years) from the MRI sub study of the KORA FF4 study were included. VAT, SAT and total body fat were quantified by a volume-interpolated VIBE-T1w-Dixon MR sequence. Hepatic fat content was determined as the proton density fat-fraction (PDFF) derived from multiecho-T1w MR sequence. Dietary intake was estimated using information provided by two different instruments, that is, repeated 24-h food lists and a food frequency questionnaire. Replacing total carbohydrates with an isoenergetic amount of total fat was significantly positively associated with VAT and hepatic fat, while there was no significant association with SAT. The multivariable adjusted β-coefficient for replacing 5% of total energy (5E%) carbohydrates with total fat was 0.42 L (95% CI: 0.04, 0.79) for VAT. A substitution in total fat intake by 5E% was associated with a significant increase in liver fat content by 23% (p-value 0.004). If reproduced in prospective studies, such findings would strongly argue for limiting dietary fat intake. View Full-Text
Keywords: hepatic fat content; visceral adipose tissue; body fat compartments; fat intake; diet; MRI hepatic fat content; visceral adipose tissue; body fat compartments; fat intake; diet; MRI
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Meisinger, C.; Rospleszcz, S.; Wintermeyer, E.; Lorbeer, R.; Thorand, B.; Bamberg, F.; Peters, A.; Schlett, C.L.; Linseisen, J. Isocaloric Substitution of Dietary Carbohydrate Intake with Fat Intake and MRI-Determined Total Volumes of Visceral, Subcutaneous and Hepatic Fat Content in Middle-Aged Adults. Nutrients 2019, 11, 1151.

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