Effects of Lactobacillus plantarum PS128 on Children with Autism Spectrum Disorder in Taiwan: A Randomized, Double-Blind, Placebo-Controlled Trial
by
Yen-Wenn Liu 1,2, Min Tze Liong 3
, Yu-Chu Ella Chung 4, Hui-Yi Huang 5, Wu-Shun Peng 1, Yun-Fang Cheng 1, Yu-Siou Lin 6, Yu-Yu Wu 7,* and Ying-Chieh Tsai 1,2,*
Yen-Wenn Liu 1,2, Min Tze Liong 3, Yu-Chu Ella Chung 4, Hui-Yi Huang 5, Wu-Shun Peng 1, Yun-Fang Cheng 1, Yu-Siou Lin 6, Yu-Yu Wu 7,* and Ying-Chieh Tsai 1,2,*
1
Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 11221, Taiwan
2
Microbiome Research Center, National Yang-Ming University, Taipei 11221, Taiwan
3
School of Industrial Technology, Universiti Sains Malaysia, Penang 11800, Malaysia
4
Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei 10050, Taiwan
5
Department of Psychology, National Taiwan University, Taipei 10090, Taiwan
6
Department of Psychology, National Chengchi University, Taipei 11605, Taiwan
7
YuNing Clinic, Taipei 10664, Taiwan
*
Authors to whom correspondence should be addressed.
Nutrients 2019, 11(4), 820; https://doi.org/10.3390/nu11040820
Received: 21 February 2019 / Revised: 29 March 2019 / Accepted: 9 April 2019 / Published: 11 April 2019
This four-week, randomized, double-blind, placebo-controlled study investigated the effects of Lactobacillus plantarum PS128 (PS128) on boys with autism spectrum disorder (ASD) aged 7–15 in Taiwan. All subjects fulfilled the criteria for ASD diagnosis of DSM-V and the Autism Diagnostic Interview-Revised (ADI-R). Questionnaires used for the primary outcome measure include the Autism Behavior Checklist-Taiwan version (ABC-T), the Social Responsiveness Scale (SRS) and the Child Behavior Checklist (CBCL). The Swanson, Nolan, and Pelham-IV-Taiwan version (SNAP-IV) and the Clinical Global Impression-improvement (CGI-I) were used for the secondary outcome measure. The results showed that PS128 ameliorated opposition/defiance behaviors, and that the total score of SNAP-IV for younger children (aged 7−12) improved significantly compared with the placebo group. Additionally, several elements were also notably improved in the PS128 group after 28-day consumption of PS128. Further studies are needed to better clarify the effects of PS128 for younger children with ASD on broader symptoms.
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Keywords:
autism spectrum disorder (ASD); psychobiotic; Lactobacillus plantarum PS128; hyperactivity; anxiety
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MDPI and ACS Style
Liu, Y.-W.; Liong, M.T.; Chung, Y.-C.E.; Huang, H.-Y.; Peng, W.-S.; Cheng, Y.-F.; Lin, Y.-S.; Wu, Y.-Y.; Tsai, Y.-C. Effects of Lactobacillus plantarum PS128 on Children with Autism Spectrum Disorder in Taiwan: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients 2019, 11, 820.
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