Impact of SchisandraChinensis Bee Pollen on Nonalcoholic Fatty Liver Disease and Gut Microbiota in HighFat Diet Induced Obese Mice

Cheng, Ni; Chen, Sinan; Liu, Xinyan; Zhao, Haoan; Cao, Wei

doi:10.3390/nu11020346

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Impact of SchisandraChinensis Bee Pollen on Nonalcoholic Fatty Liver Disease and Gut Microbiota in HighFat Diet Induced Obese Mice

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College of Food Science and Technology, Northwest University, 229 North TaiBai Road, Xi’an 710069, China

School of Chemical Engineering, Northwest University, 229 North TaiBai Road, Xi’an 710069, China

Bee Product Research Center of Shaanxi Province, Xi’an 710065, China

Authors to whom correspondence should be addressed.

Nutrients 2019, 11(2), 346; https://doi.org/10.3390/nu11020346

Received: 8 November 2018 / Revised: 25 January 2019 / Accepted: 31 January 2019 / Published: 6 February 2019

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Abstract

Schisandrachinensisbee pollen has been used as a health food in China for centuries; however, its bioactive constituents and functions are not very clear. In this study, we investigated the phenolic compounds of Schisandrachinensisbee pollen extract (SCPE) by UHPLC-Q-Orbitrap-HRMS/HPLC-DAD-ECD and its prevention from nonalcoholic fatty liver disease (NAFLD) and modulation of gut microbiota in high fat diet induced obese C57BL/6 mice. The results showed that 12 phenolic compounds were identified in SCPE, and naringenin, rutin and chrysin were the main constituents. The content of naringenin reached 1.89 mg/g, and total phenolic content (TPC) of SCPE were 101.83 mg GA/g. After obese mice were administrated with SCPE at 7.86 and 15.72 g/kg BW for 8 weeks, body weight gains were reduced by 18.23% and 19.37%. SCPE could decrease fasting blood glucose, cut down the lipid accumulation in serum and liver, lessen oxidative injury and inflammation in obesity mice. Moreover, SCPE could effectively inhibit the formation of NAFLD by inhibition of LXR-α, SREBP-1c and FAS genes expression, and modulate the structural alteration of gut microbiota in obesity mice. These findings suggested that SCPE could attenuate the features of the metabolism syndrome in obesity mice, which can be used to prevent obesity and NAFLD of human beings. View Full-Text

Keywords: Schisandrachinensisbee pollen; gut microbiota; nonalcoholic fatty liver disease; obesity; phenolic compounds

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Cheng, N.; Chen, S.; Liu, X.; Zhao, H.; Cao, W. Impact of SchisandraChinensis Bee Pollen on Nonalcoholic Fatty Liver Disease and Gut Microbiota in HighFat Diet Induced Obese Mice. Nutrients 2019, 11, 346. https://doi.org/10.3390/nu11020346

AMA Style

Cheng N, Chen S, Liu X, Zhao H, Cao W. Impact of SchisandraChinensis Bee Pollen on Nonalcoholic Fatty Liver Disease and Gut Microbiota in HighFat Diet Induced Obese Mice. Nutrients. 2019; 11(2):346. https://doi.org/10.3390/nu11020346

Chicago/Turabian Style

Cheng, Ni, Sinan Chen, Xinyan Liu, Haoan Zhao, and Wei Cao. 2019. "Impact of SchisandraChinensis Bee Pollen on Nonalcoholic Fatty Liver Disease and Gut Microbiota in HighFat Diet Induced Obese Mice" Nutrients 11, no. 2: 346. https://doi.org/10.3390/nu11020346

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Impact of SchisandraChinensis Bee Pollen on Nonalcoholic Fatty Liver Disease and Gut Microbiota in HighFat Diet Induced Obese Mice

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