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An Isocaloric Nordic Diet Modulates RELA and TNFRSF1A Gene Expression in Peripheral Blood Mononuclear Cells in Individuals with Metabolic Syndrome—A SYSDIET Sub-Study

1
Department of Nutrition, Institute for Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway
2
National Advisory Unit for Familial Hypercholesterlemia, Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, 0424 Oslo, Norway
3
Department of Nursing and Health Promotion, Faculty of Health Sciences, OsloMet—Oslo Metropolitan University, 0130 Oslo, Norway
4
Mills AS, Sofienberggt. 19, 0558 Oslo, Norway
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Department of Medicine (H7), Karolinska Institute, 17176 Stockholm, Sweden
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School of Medicine, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, 70211 Kuopio, Finland
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Department of Medicine, Endocrinology and Clinical Nutrition, Kuopio University Hospital, 70029 Kuopio, Finland
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Institute of Biomedicine, University of Eastern Finland, 70211 Kuopio, Finland
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Department of Endocrinology and Internal Medicine, Department of Clinical Medicine, Aarhus University Hospital, Aarhus University, 8200 Aarhus, Denmark
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Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, 2200 Copenhagen, Denmark
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Unit for Nutrition Research, University of Iceland and Landspitali—The National University Hospital of Iceland, 101 Reykjavík, Iceland
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Biomedical Nutrition, Pure and Applied Biochemistry, Lund University, 221 00 Lund, Sweden
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Department of Clinical Nutrition, Skåne University Hospital, 221 00 Lund, Sweden
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Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, 751 22 Uppsala, Sweden
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Institute of Clinical Medicine, Department of Internal Medicine and Biocenter Oulu, University of Oulu, Medical Research Center, Oulu University Hospital, 90220 Oulu, Finland
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Institute of Biomedicine, Biocenter of Oulu, Medical Research Center, Faculty of Medicine, University of Oulu, and Oulu University Hospital, 90220 Oulu, Finland
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Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, 60572 Poznan, Poland
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VTT Technical Research Centre of Finland, 021100 Espoo, Finland
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(12), 2932; https://doi.org/10.3390/nu11122932
Received: 30 October 2019 / Revised: 22 November 2019 / Accepted: 27 November 2019 / Published: 3 December 2019
(This article belongs to the Special Issue Health Benefits of the Nordic Diet)
A healthy dietary pattern is associated with a lower risk of metabolic syndrome (MetS) and reduced inflammation. To explore this at the molecular level, we investigated the effect of a Nordic diet (ND) on changes in the gene expression profiles of inflammatory and lipid-related genes in peripheral blood mononuclear cells (PBMCs) of individuals with MetS. We hypothesized that the intake of an ND compared to a control diet (CD) would alter the expression of inflammatory genes and genes involved in lipid metabolism. The individuals with MetS underwent an 18/24-week randomized intervention to compare a ND with a CD. Eighty-eight participants (66% women) were included in this sub-study of the larger SYSDIET study. Fasting PBMCs were collected before and after the intervention and changes in gene expression levels were measured using TaqMan Array Micro Fluidic Cards. Forty-eight pre-determined inflammatory and lipid related gene transcripts were analyzed. The expression level of the gene tumor necrosis factor (TNF) receptor superfamily member 1A (TNFRSF1A) was down-regulated (p = 0.004), whereas the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) subunit, RELA proto-oncogene, was up-regulated (p = 0.016) in the ND group compared to the CD group. In conclusion, intake of an ND in individuals with the MetS may affect immune function. View Full-Text
Keywords: metabolic syndrome; randomized controlled dietary intervention; gene expression; peripheral blood mononuclear cells; inflammation metabolic syndrome; randomized controlled dietary intervention; gene expression; peripheral blood mononuclear cells; inflammation
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Ulven, S.M.; Holven, K.B.; Rundblad, A.; Myhrstad, M.C.W.; Leder, L.; Dahlman, I.; Mello, V.D.; Schwab, U.; Carlberg, C.; Pihlajamäki, J.; Hermansen, K.; Dragsted, L.O.; Gunnarsdottir, I.; Cloetens, L.; Åkesson, B.; Rosqvist, F.; Hukkanen, J.; Herzig, K.-H.; Savolainen, M.J.; Risérus, U.; Thorsdottir, I.; Poutanen, K.S.; Arner, P.; Uusitupa, M.; Kolehmainen, M. An Isocaloric Nordic Diet Modulates RELA and TNFRSF1A Gene Expression in Peripheral Blood Mononuclear Cells in Individuals with Metabolic Syndrome—A SYSDIET Sub-Study. Nutrients 2019, 11, 2932.

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