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Interactions between DRD2/ANKK1 TaqIA Polymorphism and Dietary Factors Influence Plasma Triglyceride Concentrations in Diabetic Patients from Western Mexico: A Cross-sectional Study

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Facultad de Medicina y Psicología, Universidad Autónoma de Baja California, Tijuana, Baja California 22427, Mexico
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Unidad Especializada en Investigación, Desarrollo e Innovación en Medicina Genómica, Centro Nayarita de Innovación y Transferencia de Tecnología, Universidad Autónoma de Nayarit, Tepic, Nayarit 63155, Mexico
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Unidad Académica de Medicina, Laboratorio de Investigación en Enfermedades Crónico-Degenerativas, Universidad Autónoma de Nayarit, Tepic, Nayarit 63155, Mexico
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Departmento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco 44340, Mexico
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Hospital Civil Dr Antonio González Guevara, Servicios de Salud en Nayarit, Tepic, Nayarit 63000, Mexico
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Author to whom correspondence should be addressed.
Nutrients 2019, 11(12), 2863; https://doi.org/10.3390/nu11122863
Received: 7 September 2019 / Revised: 11 October 2019 / Accepted: 21 October 2019 / Published: 22 November 2019
This study aimed to screen relevant interactions between DRD2/ANKK1 TaqIA polymorphism and dietary intakes with reference to phenotypical features in patients with T2D from western Mexico. In this cross-sectional study, a total of 175 T2D patients were enrolled. Dietary intake was evaluated using 3-day food records and appropriate software. Glycemic and blood lipid profiles were measured by standardized methods. Genotyping of the DRD2/ANKK1 TaqIA polymorphism was performed by the RFLP method. Gene-diet interactions regarding anthropometric and metabolic phenotypes were screened by adjusted multiple linear regression analyses. Genotype frequencies of the DRD2/ANKK1 TaqIA polymorphism were A1A1 (16.0%), A1A2 (52.6%), and A2A2 (31.4%). Statistically significant interactions between the DRD2/ANKK1 TaqIA genotypes and dietary factors in relation to blood triglyceride (TG) levels were found. Carriers of the A1 allele (A1A1 homozygotes plus A1A2 heterozygotes) were protected from TG increases by maltose intake (P int. = 0.023). Instead, A2A2 homozygotes were susceptible to TG rises through consumptions of total fat (P int. = 0.041), monounsaturated fatty acids (P int. = 0.001), and dietary cholesterol (P int. = 0.019). This study suggests that the interactions between DRD2/ANKK1 TaqIA polymorphism and dietary factors (sugar and fats) influence TG levels in diabetic patients. View Full-Text
Keywords: diabetes; DRD2/ANKK1 TaqIA polymorphism; diet; triglycerides; personalized nutrition diabetes; DRD2/ANKK1 TaqIA polymorphism; diet; triglycerides; personalized nutrition
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Ramos-Lopez, O.; Mejia-Godoy, R.; Frías-Delgadillo, K.J.; Torres-Valadez, R.; Flores-García, A.; Sánchez-Enríquez, S.; Aguiar-García, P.; Martínez-López, E.; Zepeda-Carrillo, E.A. Interactions between DRD2/ANKK1 TaqIA Polymorphism and Dietary Factors Influence Plasma Triglyceride Concentrations in Diabetic Patients from Western Mexico: A Cross-sectional Study. Nutrients 2019, 11, 2863.

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