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Vitamin D Levels in Women with Polycystic Ovary Syndrome: A Population-Based Study

by 1,2,3,4,*, 5,6,7,8, 6, 1,2,3, 5,7,8,9, 2,7,10,11, 5,12, 1,2,4,† and 1,2,3,†
1
PEDEGO Research Unit (Research Unit for Pediatrics, Dermatology, Clinical Genetics, Obstetrics and Gynecology), University of Oulu, 90014 Oulu, Finland
2
Medical Research Center Oulu (MRC Oulu), University of Oulu, 90014 Oulu, Finland
3
Department of Obstetrics and Gynecology, Oulu University Hospital, 90220 Oulu, Finland
4
Department of Pediatrics and Adolescence, Oulu University Hospital, 90220 Oulu, Finland
5
Center for Life-Course Health Research, Faculty of Medicine, University of Oulu, 90014 Oulu, Finland
6
Infrastructure for Population Studies, Faculty of Medicine, University of Oulu, 90014 Oulu, Finland
7
Biocenter Oulu, University of Oulu, 90014 Oulu, Finland
8
Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College, London W2 1PG, UK
9
Department of Life Sciences, College of Health and Life Sciences, Brunel University London, Kingston Lane, Uxbridge, Middlesex UB8 3PH, UK
10
Institute of Biomedicine, University of Oulu, 90014 Oulu, Finland
11
Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, 61-701 Poznan, Poland
12
Oulunkaari Health Center, 91100 Ii, Finland
*
Author to whom correspondence should be addressed.
Equal contribution.
Nutrients 2019, 11(11), 2831; https://doi.org/10.3390/nu11112831
Received: 24 October 2019 / Revised: 8 November 2019 / Accepted: 15 November 2019 / Published: 19 November 2019
Background: Conflicting evidence supports a role for vitamin D in women with reproductive disorders such as polycystic ovary syndrome (PCOS) but studies on large, unselected populations have been lacking. Methods: We conducted a general population-based study from the prospective Northern Finland Birth Cohort 1966 (NFBC1966). Serum 25-hydroksyvitamin D (25(OH)D) levels were evaluated in women with self-reported PCOS (n = 280) versus non-symptomatic controls (n = 1573) at the age of 31 with wide range of endocrine and metabolic confounders. Results: The levels of 25(OH)D were similar among women with and without self-reported PCOS (50.35 vs. 48.30 nmol/L, p = 0.051). Women with self-reported PCOS presented with a higher body mass index (BMI), increased insulin resistance, and low-grade inflammation and testosterone levels compared to controls. The adjusted linear regression model showed a positive association between total 25(OH)D levels in self-reported PCOS (β = 2.46, 95% confidence interval (CI) 0.84 to 4.08, p = 0.003). The result remained after adjustment for BMI, testosterone, homeostatic model assessment of insulin resistance (HOMA-IR), and high-sensitivity C-reactive protein (hs-CRP) levels. Conclusion: In this population-based setting, PCOS was associated with higher vitamin D levels when adjusting for confounding factors, without distinct beneficial effects on metabolic derangements. View Full-Text
Keywords: vitamin D; 25(OH)D; polycystic ovary syndrome; population-based study; community setting; body mass index vitamin D; 25(OH)D; polycystic ovary syndrome; population-based study; community setting; body mass index
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MDPI and ACS Style

Lumme, J.; Sebert, S.; Pesonen, P.; Piltonen, T.; Järvelin, M.-R.; Herzig, K.-H.; Auvinen, J.; Ojaniemi, M.; Niinimäki, M. Vitamin D Levels in Women with Polycystic Ovary Syndrome: A Population-Based Study. Nutrients 2019, 11, 2831. https://doi.org/10.3390/nu11112831

AMA Style

Lumme J, Sebert S, Pesonen P, Piltonen T, Järvelin M-R, Herzig K-H, Auvinen J, Ojaniemi M, Niinimäki M. Vitamin D Levels in Women with Polycystic Ovary Syndrome: A Population-Based Study. Nutrients. 2019; 11(11):2831. https://doi.org/10.3390/nu11112831

Chicago/Turabian Style

Lumme, Johanna; Sebert, Sylvain; Pesonen, Paula; Piltonen, Terhi; Järvelin, Marjo-Riitta; Herzig, Karl-Heinz; Auvinen, Juha; Ojaniemi, Marja; Niinimäki, Maarit. 2019. "Vitamin D Levels in Women with Polycystic Ovary Syndrome: A Population-Based Study" Nutrients 11, no. 11: 2831. https://doi.org/10.3390/nu11112831

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