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Article

Calorie Restriction in Adulthood Reduces Hepatic Disorders Induced by Transient Postnatal Overfeeding in Mice

1
DOHaD Laboratory, Woman-Mother-Child Department, Division of Pediatrics, Centre Hospitalier Universitaire Vaudois and University of Lausanne, 1011 Lausanne, Switzerland
2
Equipe Physiopathologie et Epidémiologie Cérébro-Cardiovasculaires (PEC2, EA7460), UFR Sciences de Santé, Université de Bourgogne Franche-Comté, 21000 Dijon, France
*
Author to whom correspondence should be addressed.
Whose contributions are equal.
Nutrients 2019, 11(11), 2796; https://doi.org/10.3390/nu11112796
Received: 9 October 2019 / Revised: 12 November 2019 / Accepted: 14 November 2019 / Published: 16 November 2019
(This article belongs to the Special Issue Early Overnutrition and Long-Term Health Effects)
Impaired early nutrition influences the risk of developing metabolic disorders in later life. We observed that transient postnatal overfeeding (OF) in mice induces long-term hepatic alterations, characterized by microsteatosis, fibrosis associated with oxidative stress (OS), and stress-induced premature senescence (SIPS). In this study, we investigated whether such changes can be reversed by moderate calorie restriction (CR). C57BL/6 male mice pups were maintained during lactation in litters adjusted to nine pups in the normal feeding (NF) group and three pups in the transient postnatal OF group. At six months of age, adult mice from the NF and OF groups were randomly assigned to an ad libitum diet or CR (daily energy supply reduced by 20%) for one month. In each group, at the age of seven months, analysis of liver structure, liver markers of OS (superoxide anion, antioxidant defenses), and SIPS (lipofuscin, p53, p21, p16, pRb/Rb, Acp53, sirtuin-1) were performed. CR in the OF group reduced microsteatosis, decreased levels of superoxide anion, and increased protein expression of catalase and superoxide dismutase. Moreover, CR decreased lipofuscin staining, p21, p53, Acp53, and p16 but increased pRb/Rb and sirtuin-1 protein expression. CR did not affect the NF group. These results suggest that CR reduces hepatic disorders induced by OF. View Full-Text
Keywords: liver; developmental programming; stress-induced premature senescence; oxidative stress; reversibility; DOHaD liver; developmental programming; stress-induced premature senescence; oxidative stress; reversibility; DOHaD
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MDPI and ACS Style

Yzydorczyk, C.; Li, N.; Rigal, E.; Chehade, H.; Mosig, D.; Armengaud, J.B.; Rolle, T.; Krishnasamy, A.; Orozco, E.; Siddeek, B.; Juvet, C.; Vergely, C.; Simeoni, U. Calorie Restriction in Adulthood Reduces Hepatic Disorders Induced by Transient Postnatal Overfeeding in Mice. Nutrients 2019, 11, 2796. https://doi.org/10.3390/nu11112796

AMA Style

Yzydorczyk C, Li N, Rigal E, Chehade H, Mosig D, Armengaud JB, Rolle T, Krishnasamy A, Orozco E, Siddeek B, Juvet C, Vergely C, Simeoni U. Calorie Restriction in Adulthood Reduces Hepatic Disorders Induced by Transient Postnatal Overfeeding in Mice. Nutrients. 2019; 11(11):2796. https://doi.org/10.3390/nu11112796

Chicago/Turabian Style

Yzydorczyk, Catherine; Li, Na; Rigal, Eve; Chehade, Hassib; Mosig, Dolores; Armengaud, Jean B.; Rolle, Thibaud.; Krishnasamy, Anithan; Orozco, Eulalia; Siddeek, Benazir; Juvet, Christian; Vergely, Catherine; Simeoni, Umberto. 2019. "Calorie Restriction in Adulthood Reduces Hepatic Disorders Induced by Transient Postnatal Overfeeding in Mice" Nutrients 11, no. 11: 2796. https://doi.org/10.3390/nu11112796

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